14394-60-6

Basic information

• Product Name: 2-Chloro-6-methylpyrimidin-4-ylamine
• Synonyms: 2-CHLORO-6-METHYLPYRIMIDIN-4-YLAMINE;4-Pyrimidinamine, 2-chloro-6-methyl- (9CI);2-Chloro-6-methyl-4-pyrimidinylamine;2-CHLOR-6-METHYLPYRIMIDIN-4-YLAMINE;2-Chloro-6-methylpyrimidin-4-ylamine ,97%;4-amino-2-chloro-6-methylpyrimidine;2-chloro-6-methyl-pyrimid...;2-Chloro-6-methylpyrimidin-4-amine, 4-Amino-2-chloro-6-methyl-1,3-diazine
• CAS NO: 14394-60-6
• Molecular Formula: C₅H₆ClN₃
• Molecular Weight: 143.57
• Product Categories: PYRIMIDINE;pharmacetical
• Mol File: 14394-60-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 215 °C
• Boiling Point: 312.9oC at 760 mmHg
• Flash Point: 143oC
• Appearance: /
• Density: 1.349g/cm3
• Vapor Pressure: 0.000514mmHg at 25°C
• Refractive Index: 1.599
• PKA: 3.04±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-6-methylpyrimidin-4-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-methylpyrimidin-4-ylamine(14394-60-6)
• EPA Substance Registry System: 2-Chloro-6-methylpyrimidin-4-ylamine(14394-60-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• Hazardous Substances Data: 14394-60-6(Hazardous Substances Data)

Usage

Description

2-Chloro-6-methylpyrimidin-4-ylamine is an organic compound characterized by its white solid appearance. It is a derivative of pyrimidine, a heterocyclic aromatic organic compound, with a chlorine atom at the 2nd position, a methyl group at the 6th position, and an amine functional group at the 4th position. 2-Chloro-6-methylpyrimidin-4-ylamine is known for its utility in various chemical reactions and organic synthesis processes.

Uses

Used in Organic Synthesis:
2-Chloro-6-methylpyrimidin-4-ylamine is used as a valuable intermediate in the field of organic synthesis for the development of various chemical compounds. Its unique structure allows it to participate in a range of reactions, making it a versatile building block for creating complex molecules with specific properties and applications.
The compound's chemical properties, including the presence of the chlorine atom and the amine group, enable it to undergo substitution, addition, and other types of reactions, facilitating the synthesis of a wide array of organic compounds. These synthesized compounds can then be utilized in different industries, such as pharmaceuticals, agrochemicals, and materials science, for various applications, including the development of new drugs, pesticides, and advanced materials.

InChI:InChI=1/C5H6ClN3/c1-3-2-4(7)9-5(6)8-3/h2H,1H3,(H2,7,8,9)

Upstream product

• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 7664-41-7 ammonia 

Downstream Products

• 24888-93-5 6-methyl-2-(methylsulfanyl)pyrimidin-4-amine 
• 51870-75-8 4-Amino-2-methoxy-6-methylpyrimidin 
• 120735-22-0 6-methyl-2-(4-nitro-phenylsulfanyl)-pyrimidin-4-ylamine 
• 18160-01-5 2-(4-amino-6-methyl-pyrimidin-2-ylamino)-benzoic acid 
• 62899-05-2 6-methyl-N²-phenylpyrimidine-2,4-diamine 
• 108718-86-1 N-(4-amino-6-methyl-pyrimidin-2-yl)-anthranilic acid ethyl ester 
• 3435-28-7 6-methylpyrimidin-4-ylamine 
• 33575-13-2 2-Hydrazino-4-amino-6-methyl-pyrimidin 

Relevant articles and documents

Preparation method of 2-chloro-4-amino-6-methylpyrimidine compound

The invention discloses a preparation method of a 2-chloro-4-amino-6-methylpyrimidine compound. The preparation method comprises the steps that 2,4-dichloro-6-methylpyrimidine is used as a raw material, dimethylsulfoxide is used as a solvent, under the temperature of 40 DEG C to 45 DEG C, ammonia gas is introduced for substitution reaction, a required isomer product 2-chloro-4-amino-6-methylpyrimidine with high conversion is obtained, and then is treated into salt after acidification, and the pure final product 2-chloro-4-amino-6-methylpyrimidine compound is obtained by dissociating. Accordingto the preparation method, a purification and separation process which is more conductive to factory scale-up production is provided, the method is easy to operate, the post-treatment operation is simple, column chromatography is not required, salifying and dissociating are only required to purify the product, thus the part-level scale-up production of the product can be effectively achieved, theshortcomings of two routes in an existing technical literature are effectively overcome, and thus the disclosed preparation method has great economic value for lowering the cost.

Pyri(mi)dyl-oxy-and -thio-benzoic acid derivatives useful as herbicides and plant growth regulants

New pyri(mi)dyl-oxy- or -thio-benzoic acid derivatives of the formula STR1 are taught which have herbicidal and plant growth regulating activity. In the formula Z can be Ch or N, X is oxygen or sulphur, A is oxygen, sulphur, a radical R5 --N=or a radical R6 O--N=and B is oxygen, sulphur, a radical STR2 with the proviso that at least one of the radicals R1, R2 or R3 represents alkyl or a part of a 3- to 6-membered fused carbocyclic ring.