143951-69-3

Basic information

• Product Name: 3-Pyridinecarbonitrile, 2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propoxy]-5-imidazo[1,2 -a]pyridin-6-yl-6-methyl-
• CAS NO: 143951-69-3
• Molecular Formula: C28H31N5O3
• Molecular Weight: 485.586
• Mol File: 143951-69-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propoxy]-5-imidazo[1,2 -a]pyridin-6-yl-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propoxy]-5-imidazo[1,2 -a]pyridin-6-yl-6-methyl-(143951-69-3)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propoxy]-5-imidazo[1,2 -a]pyridin-6-yl-6-methyl-(143951-69-3)

Safety Data

• Hazardous Substances Data: 143951-69-3(Hazardous Substances Data)

Upstream product

• 106730-54-5 olprinone 
• 57267-21-7 N-methyl-<2-(3,4-dimethoxyphenyl)ethyl>amine hydroiodide 
• 143951-92-2 2-(3-chloropropyloxy)-5-imidazo<1,2-a>pyridin-6-yl-6-methyl-3-pyridinecarbonitrile 

Relevant articles and documents

Imidazo[1,2-a]pyridines. III. Synthesis and bradycardic activity of new 5-imidazo[1,2-a]pyridin-6-ylpyridine derivatives

Structural modification of the cardiotonic agent, loprinone (E-1020, 1), suggested by data that it has a less positive chronotropic effect than milrinone (15), led us to find novel bradycardic agents that were structurally different from homoveratryl amine derivatives. Alkyl-oxy, -thio, and -amino derivatives at the 2-position of the pyridine ring of 1 produced bradycardic activity without a significant effect on blood pressure and myocardial contractility. Aryloxy analogues also decreased beart rate, and members with an electron-withdrawing group at the ortho position of the phenyl ring showed higher activity. Replacement of the imidazo[1,2-a]pyridine with pyridine resulted in diminished activity. The mechanism of bradycardic activity of these compounds seems to be direct action on the sinus node.