1439617-99-8Relevant articles and documents
Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase
Hayashi, Daisuke,Kato, Nobuo,Kuzuyama, Tomohisa,Sato, Yasuo,Ohkanda, Junko
supporting information, p. 5535 - 5537 (2013/07/26)
N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0 μM. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH-lactate dehydrogenase (LDH) is also reported.