1439921-18-2

Basic information

• Product Name: 3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole
• Synonyms: 3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole
• CAS NO: 1439921-18-2
• Molecular Weight: 229.202
• Mol File: 1439921-18-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole(1439921-18-2)
• EPA Substance Registry System: 3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole(1439921-18-2)

Safety Data

• Hazardous Substances Data: 1439921-18-2(Hazardous Substances Data)

Upstream product

• 68843-67-4 1-phenyl-but-3-en-1-one oxime 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 887144-94-7 Togni's reagent II 

Relevant articles and documents

Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines

Cheap and commercially available trichloroisocyanuric acid has been used to promote trifluoromethylation by using TMSCF3 as the trifluoromethyl source. The method provides a novel and efficient protocol for the construction of CF3-containing 4,5-dihydroisoxazoles from allylic oximes in good to excellent yields.