1439937-69-5Relevant articles and documents
Enantioselective Michael addition/iminium ion cyclization cascades of tryptamine-derived ureas
Aillaud, Isabelle,Barber, David M.,Thompson, Amber L.,Dixon, Darren J.
, p. 2946 - 2949 (2013/07/26)
A Michael addition/iminium ion cyclization cascade of enones with tryptamine-derived ureas under BINOL phosphoric acid (BPA) catalysis is reported. The cascade reaction tolerates a wide variety of easily synthesized tryptamine-derived ureas, including those bearing substituents on the distal nitrogen atom of the urea moiety, affording polyheterocyclic products in good yields and good to excellent enantioselectivities.