1440-28-4

Basic information

• Product Name: 3-(morpholin-4-yl)-3-oxo-2-phenyl-propionitrile
• Synonyms: 3-(morpholin-4-yl)-3-oxo-2-phenyl-propionitrile
• CAS NO: 1440-28-4
• Molecular Weight: 230.266
• Mol File: 1440-28-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(morpholin-4-yl)-3-oxo-2-phenyl-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(morpholin-4-yl)-3-oxo-2-phenyl-propionitrile(1440-28-4)
• EPA Substance Registry System: 3-(morpholin-4-yl)-3-oxo-2-phenyl-propionitrile(1440-28-4)

Safety Data

• Hazardous Substances Data: 1440-28-4(Hazardous Substances Data)

Upstream product

• 15159-40-7 4-morpholinocarbonyl chloride 
• 75-05-8 acetonitrile 
• 164594-13-2 Phenyl[2-(trimethylsilyl)phenyl]iodonium trifluoromethanesulfonate 

Relevant articles and documents

Facile one-pot synthesis of 2-aryl-substituted nitriles and 2-aryl-3-keto nitriles via benzyne reaction

2-Aryl-substituted nitriles were prepared in good to excellent yields in a one-pot reaction by the reaction of benzyne, generated using neutral conditions from (phenyl)[o-(trimethylsilyl)-phenyl]iodonium triflate, and 2-lithionitriles. 3-Keto nitriles substituted at the 2-position were obtained in good yields when these reactions were trapped with acid chlorides. The mechanism of the benzyne reaction in terms of a N-lithiobenzocyclobutanimine intermediate is discussed. Copyright Taylor & Francis Group, LLC.