144017-65-2 Usage
Description
(R)-(+)-1-(benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol, also known as (R)-Stiripentol, is a chiral molecule with a unique structure that features a benzo[d][1,3]dioxol-5-yl group attached to a 4,4-dimethylpent-1-en-3-ol backbone. (R)-(+)-1-(benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol is an S-isomer of Stiripentol (S686825), which is a pharmaceutical drug used in the treatment of epilepsy. The (R)-enantiomer exhibits distinct properties and applications compared to its S-isomer, making it a valuable compound for various purposes.
Uses
Used in Pharmaceutical Industry:
(R)-(+)-1-(benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol is used as an active pharmaceutical ingredient for the treatment of epilepsy. It functions as a co-therapy agent, working in conjunction with other anti-convulsant medications to enhance their effectiveness. The compound inhibits the enzymes responsible for the metabolism of these anti-convulsant agents, thereby increasing their concentration in the body and improving their therapeutic action.
Used in Drug Metabolism Research:
In addition to its direct application in epilepsy treatment, (R)-(+)-1-(benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol can also be utilized in the field of drug metabolism research. Its ability to inhibit specific enzymes involved in the metabolism of anti-convulsant agents makes it a valuable tool for studying enzyme inhibition mechanisms and the development of novel drug therapies.
Used in Drug Delivery Systems:
Similar to gallotannin, (R)-(+)-1-(benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol can be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound can be more effectively delivered to target cells, enhancing its overall efficacy in treating epilepsy and potentially other conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 144017-65-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,1 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 144017-65:
(8*1)+(7*4)+(6*4)+(5*0)+(4*1)+(3*7)+(2*6)+(1*5)=102
102 % 10 = 2
So 144017-65-2 is a valid CAS Registry Number.
144017-65-2Relevant articles and documents
Synthesis of the antiepileptic (R)-Stiripentol by a combination of lipase catalyzed resolution and alkene metathesis
El-Behairy, Mohammed Farrag,Sundby, Eirik
, p. 285 - 289 (2013)
The enantiopure (ee >99%) antiepileptic (R)-(+)-Stiripentol has been stereoselectively synthesized via cross metathesis of 5-vinylbenzo[d][1,3] dioxole 1 and (R)-(+)-4,4-dimethylpent-1-en-3-ol (R)-(+)-2. A novel one-pot two-step pathway for the synthesis of 5-vinylbenzo[d][1,3]dioxole 1 starting from 3,4-dihydroxycinnamic acid has been introduced. A lipase catalyzed kinetic resolution access to enantiopure (R)-(+)-4,4-dimethylpent-1-en-3-ol (R)-(+)-2 (ee >99%) has also been developed.
