14403-45-3 Usage
Description
L-B-IMIDAZOLELACTIC ACID, MONOHYDRATE is an organic compound that serves as an intermediate in the synthesis of imidazole alkaloids, specifically (+)-pilocarpine and (+)-isopilocarpine. It is a white solid with unique chemical properties that make it valuable in various applications.
Uses
Used in Pharmaceutical Industry:
L-B-IMIDAZOLELACTIC ACID, MONOHYDRATE is used as a key intermediate in the synthesis of imidazole alkaloids for the pharmaceutical industry. Its role in creating (+)-pilocarpine and (+)-isopilocarpine is crucial, as these alkaloids have significant therapeutic applications, particularly in the treatment of various medical conditions.
Used in Chemical Synthesis:
L-B-IMIDAZOLELACTIC ACID, MONOHYDRATE is also used as a versatile building block in the chemical synthesis of other imidazole-containing compounds. Its unique structure allows for the creation of a wide range of molecules with diverse applications, from pharmaceuticals to agrochemicals.
Used in Research and Development:
In the field of research and development, L-B-IMIDAZOLELACTIC ACID, MONOHYDRATE is employed as a valuable compound for studying the properties and reactivity of imidazole-containing molecules. This helps scientists and researchers to better understand the structure-activity relationships and develop new drugs or materials with improved properties.
Check Digit Verification of cas no
The CAS Registry Mumber 14403-45-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,0 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14403-45:
(7*1)+(6*4)+(5*4)+(4*0)+(3*3)+(2*4)+(1*5)=73
73 % 10 = 3
So 14403-45-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O3/c9-5(6(10)11)1-4-2-7-3-8-4/h2-3,5,9H,1H2,(H,7,8)(H,10,11)/t5-/m0/s1
14403-45-3Relevant articles and documents
Synthesis and evaluation of deglycobleomycin A2 analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: Direct functional characterization of the requirement for secondary amide metal complexation
Boger, Dale L.,Teramoto, Shuji,Cai, Hui
, p. 179 - 193 (2007/10/03)
The synthesis and comparative examination of 3-5, analogues of deglycobleomycin A2 (2) which address the inferred importance of the L-histidine secondary amide directly, are detailed. The agent 3 lacks only the L-histidine β-hydroxy group of deglycobleomycin A2 and the corresponding agents 4 and 5 incorporate a tertiary N-methyl amide and simple ester in place of the L-histidine secondary amide. The DNA cleavage properties of 3 proved essentially indistinguishable from those of deglycobleomycin A2 (2) confirming that the distinctions between bleomycin A2 (1) and deglycobleomycin (2) are due to the removal of the disaccharide and not the introduction of the L-histidine free β-hydroxy group. The agents 4 and 5 containing a tertiary N-methyl amide and ester in place of the L-histidine secondary amide were found to cleave duplex DNA but to do so in a nonsequence selective fashion with a substantially reduced efficiency and a diminished double to single strand cleavage ratio that are only slightly greater than that of free iron itself. These latter observations establish the functional requirement for the L-histidine secondary amide and are consistent with the proposals that the L-histidine deprotonated secondary amide is required for functional metal chelation and activity.
