1440430-76-1

Basic information

• Product Name: (2'S,4'R,6'S)-2'-(3''',4'''-methylenedioxyphenethyl)-6'-(4''''-hydroxy-3''''-methoxyphenyl)tetrahydropyran-4'-yl acetate
• CAS NO: 1440430-76-1
• Molecular Weight: 414.455
• Mol File: 1440430-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2'S,4'R,6'S)-2'-(3''',4'''-methylenedioxyphenethyl)-6'-(4''''-hydroxy-3''''-methoxyphenyl)tetrahydropyran-4'-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2'S,4'R,6'S)-2'-(3''',4'''-methylenedioxyphenethyl)-6'-(4''''-hydroxy-3''''-methoxyphenyl)tetrahydropyran-4'-yl acetate(1440430-76-1)
• EPA Substance Registry System: (2'S,4'R,6'S)-2'-(3''',4'''-methylenedioxyphenethyl)-6'-(4''''-hydroxy-3''''-methoxyphenyl)tetrahydropyran-4'-yl acetate(1440430-76-1)

Safety Data

• Hazardous Substances Data: 1440430-76-1(Hazardous Substances Data)

Upstream product

• 2754-27-0 trimethylsilyl acetate 
• 1440432-69-8 (S)-1-(3',4'-methylenedioxy)-hex-5-ene-3-ol 
• 121-33-5 vanillin 
• 30830-55-8 3-(3,4-methylenedioxyphenyl)propionaldehyde 
• 7031-03-0 3-(benzo[d][1,3]dioxol-5-yl)propan-1-ol 

Relevant articles and documents

A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin

A Prins cyclization between a polymerbound aldehyde and a homoallylic alcohol served as the key step in the synthesis of tetrahydropyran derivatives. A phenotypic screen led to the identification of compounds that inhibit mitosis (as seen by the accumulation of round cells with condensed DNA and membrane blebs; see picture). These compounds were termed tubulexins as they target the CSE1L protein and the vinca alkaloid binding site of tubulin.