144221-11-4Relevant articles and documents
Nazarov cyclization of 1,4-pentadien-3-ols: Preparation of cyclopenta[b]indoles and spiro[indene-1,4′-quinoline]s
Wang, Zhiming,Xu, Xingzhu,Gu, Zhanshou,Feng, Wei,Qian, Houjun,Li, Zhengyi,Sun, Xiaoqiang,Kwon, Ohyun
, p. 2811 - 2814 (2016/02/18)
The first Lewis acid-catalyzed intramolecular interrupted Nazarov cyclization of 1,4-pentadien-3-ols is described. Using FeBr3 as the catalyst, a series of new substituted cyclopenta[b]indoles was prepared - through a sequence of Nazarov cyclization, nucleophilic amination, and isomerization - with good yields and high diastereo- and regioselectivities. A similar catalytic process was also developed for the synthesis of structurally interesting spiro[indene-1,4′-quinoline]s.
