1442476-69-8

Basic information

• Product Name: (1E,4E)-1-(furan-2-yl)-5-(4-(6-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one
• Synonyms: (1E,4E)-1-(furan-2-yl)-5-(4-(6-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one
• CAS NO: 1442476-69-8
• Molecular Weight: 382.419
• Mol File: 1442476-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1E,4E)-1-(furan-2-yl)-5-(4-(6-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,4E)-1-(furan-2-yl)-5-(4-(6-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one(1442476-69-8)
• EPA Substance Registry System: (1E,4E)-1-(furan-2-yl)-5-(4-(6-methylquinazolin-4-yloxy)phenyl)penta-1,4-dien-3-one(1442476-69-8)

Safety Data

• Hazardous Substances Data: 1442476-69-8(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 19181-53-4 6-methyl-3H-quinazolin-4-one 
• 22214-30-8 (E)-4-(4-hydroxyphenyl)-3-buten-2-one 
• 58421-79-7 4-chloro-6-methylquinazoline 
• 98-01-1 furfural 
• 1442476-87-0 (E)-4-(4-(6-methylquinazolin-4-yloxy)phenyl)but-3-en-2-one 

Relevant articles and documents

Synthesis and antiviral bioactivity of novel (1E, 4E)-1-aryl-5-(2- (quinazolin-4-yloxy)phenyl)-1,4-pentadien-3-one derivatives

A series of novel (1E, 4E)-1-aryl-5-[2-(quinazolin-4-yloxy)phenyl]-1,4- pentadien-3-one derivatives were designed and synthesized by reacting substituent aldehyde with intermediates 4a-f. Antiviral bioassays indicated that most of the compounds exhibited promising ex vivo antiviral bioactivities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) at 500 μg/mL. The relationship between structure and antiviral activity was also discussed. Compounds 5a, 6e, and 6g could possess appreciable protective bioactivities on TMV ex vivo by approximately 50% (EC50) at 257.7, 320.7 and 243.3 μg/mL. This study is the first to demonstrate that (1E, 4E)-1-aryl-5-(2-(quinazolin-4-yloxy)phenyl)-1,4-pentadien-3-one can be used to develop potential virucides for plants.