14428-49-0

Basic information

• Product Name: 2-(4-chlorophenyl)-4-methylquinoline
• Synonyms: 2-(4-chlorophenyl)-4-methylquinoline
• CAS NO: 14428-49-0
• Molecular Weight: 253.731
• Mol File: 14428-49-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-4-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-4-methylquinoline(14428-49-0)
• EPA Substance Registry System: 2-(4-chlorophenyl)-4-methylquinoline(14428-49-0)

Safety Data

• Hazardous Substances Data: 14428-49-0(Hazardous Substances Data)

Upstream product

• 116-11-0 2-Methoxypropene 
• 1613-95-2 (E)-1-(4-chlorophenyl)-N-phenylmethanimine 
• 80379-10-8 1-(2-nitrophenyl)ethan-1-ol 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 99-91-2 para-chloroacetophenone 
• 551-93-9 2-aminoacetophenone 
• 577-59-3 2-acetylnitrobenzene 
• 122-01-0 4-chloro-benzoyl chloride 
• 52562-19-3 2-isopropenylaniline 
• 148336-14-5 4-chloro-N-(2-(prop-1-en-2-yl)phenyl)benzamide 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 4053-40-1 4-methylquinoline 1-oxide 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 148336-22-5 2-(4-Chloro-phenyl)-quinoline-4-carbaldehyde 

Relevant articles and documents

Perylenequinonoid-catalyzed photoredox activation for the direct arylation of (het)arenes with sunlight

Naturally occurring perylenequinonoid pigments (PQPs) have attracted considerable attention owing to their excellent properties of photosensitization. They have been widely investigated as an aspect of photophysics and photobiology. However, their applications in photocatalysis are yet to be explored. We report here that sunlight along with 1 mol% cercosporin, which is one of the perylenequinonoid pigments, catalyzes the direct C-H bond arylation of (het)arenes by a photoredox process with good regioselectivity and broad functional group compatibility. Furthermore, a gram-scale reaction with great conversions of substrates was achieved even by a cercosporin-containing supernatant without organic solvent extraction and purification after liquid fermentation. Thus we set up a bridge between microbial fermentation and organic photocatalysis for chemical reactions in a sustainable, environmentally friendly manner.

Quantitative structure activity relationship and biological activity studies of 4-methyl-2-(4-substituted phenyl)quinoline derivatives

Quantitative structure activity relationship (QSAR) studies of some 4-methyl-2-(4-substituted phenyl)quinoline derivatives were carried out to determine their predicted biological activities. Numbers of descriptors were tested to adjudge a quantitative correlation between activity and structural features using training set and test set. Significant correlation was observed between activities and descriptors. The results were interpreted on the basis of linear regression analysis. Experimental antibacterial activities of the test set compounds were determined. The predicted biological activities generated by QSAR model were compared with the experimental antibacterial activities. The concurrence between the predicted and experimental biological activities validates the QSAR model. Thus, it can be concluded that the model under the present investigation can be applied for predicting the unknown biological activities of structurally similar molecules.

Iron-Catalyzed Cyclization of Nitrones with Geminal-Substituted Vinyl Acetates: A Direct [4 + 2] Assembly Strategy Leading to 2,4-Disubstituted Quinolines

An iron-catalyzed intermolecular [4 + 2] cyclization of arylnitrones with geminal-substituted vinyl acetates was developed for the synthesis of 2,4-disubstituted quinolines in moderate to good yields with good functional group compatibilities. Preliminary mechanistic studies suggest a plausible iron-catalyzed C-H activation process under external-oxidant-free conditions.