144293-91-4

Basic information

• Product Name: N'-[(E)-(2,4-dichloro-phenyl)methylidene]isonicotinohydrazide
• Synonyms: N'-[(E)-(2,4-dichloro-phenyl)methylidene]isonicotinohydrazide
• CAS NO: 144293-91-4
• Molecular Weight: 294.14
• Mol File: 144293-91-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N'-[(E)-(2,4-dichloro-phenyl)methylidene]isonicotinohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-[(E)-(2,4-dichloro-phenyl)methylidene]isonicotinohydrazide(144293-91-4)
• EPA Substance Registry System: N'-[(E)-(2,4-dichloro-phenyl)methylidene]isonicotinohydrazide(144293-91-4)

Safety Data

• Hazardous Substances Data: 144293-91-4(Hazardous Substances Data)

Upstream product

• 54-85-3 isoniazid 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 160816-77-3 5-(2,4-dichlorophenyl)-4-methyl-2-(4-pyridyl)-Δ²-1,3,4-oxadiazoline 
• 906820-54-0 2-(2,4-dichlorophenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole 
• 144294-06-4 N-[2-(2,4-Dichloro-phenyl)-1,1,4-trioxo-1λ⁶-thiazolidin-3-yl]-isonicotinamide 
• 144293-98-1 N-[2-(2,4-Dichloro-phenyl)-4-oxo-thiazolidin-3-yl]-isonicotinamide 

Relevant articles and documents

Antimicrobial activities of synthetic arylidine nicotinic and isonicotinic hydrazones

Background: Despite availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. Identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. Methods: A library of synthetic arylidene nicotinic and isonicotinic hydrazones (1-63) were investigated for antimicrobial activities. Results: A number of derivatives showed significant to moderate antimicrobial activities against Gram positive and Gram negative bacterial cultures. Few compounds also showed antifungal activity against fungal cultures. Minimum Inhibitory Concentration (MIC) was calculated for the most active compounds 1, 7, 11, 19, 34, 46, 50, 51, and 55 against gram positive and gram negative cultures. Conclusion: Newly identified compounds may serve as lead for future research in order to get the more powerful antibacterial agents.

Eco-friendly and highly efficient synthesis, including multigram synthesis, of aldehyde isonicotinoyl hydrazones using sonochemistry

Background: The isoniazid has been a key compound in first-line tuberculosis (TB) treatment, usually in combination with other drugs. Following on from the use of isoniazid itself, various derivatives of isoniazid have also been investigated as anti-TB ag

Synthesis, oxidation and dehydrogenation of cyclic N,O- and N,S-acetals. Part III. [1,2] Transformation of N,O-acetals: 3-Acyl-1,3,4-oxadiazolines

(Chemical Equation Presented) Various aldehyde and ketone acylhydrazones are synthesized and, under acylating conditions, cyclized into 3-acyl-1,3,4-oxadiazolines. The scope and limitations of these cyclizations and the possible side reactions (e.g. formation of the open-chain N,O-acylhydrazinocarbinols) are dissected. For the first time, simple, convenient and efficient dehydrogenations of 3-acyl-1,3,4-oxadiazolines to oxadiazoles by treatment with potassium permanganate, or more conveniently, with ammonium cerium(IV) nitrate (CAN) are presented. CAN oxidation of 2,2-disubstituted 3-acyl-1,3,4-oxadiazolines, as well as that of aldehyde diacylhydrazones (open-chain isomers of 2,5-disubstituted 3-acyl-1,3,4- oxadiazolines) regenerates the parent carbonyl compounds.