1443-54-5 Usage
Description
N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride, also known as Fentanyl (hydrochloride) (CRM) (Item No. ISO60197), is a certified reference material classified as an opioid. It is a synthetic compound that is significantly more potent than morphine in terms of pain relief but also carries a higher risk of lethality. Due to its high potential for abuse and the numerous fatal overdoses associated with it, Fentanyl is regulated as a Schedule II compound in the United States. The hydrochloride salt form of Fentanyl is provided as a DEA exempt preparation, making it suitable for research and forensic applications.
Uses
Used in Pharmaceutical Industry:
N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride is used as an analgesic agent for its potent pain-relieving properties. It is particularly effective in managing severe pain, such as post-surgical pain or chronic pain conditions, due to its high efficacy compared to other opioids.
Used in Research and Forensic Applications:
In the fields of research and forensic science, N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride serves as a certified reference material. It is utilized for the development, validation, and standardization of analytical methods and procedures related to opioid detection and quantification. This is crucial for ensuring the accuracy and reliability of test results in both research and forensic settings.
Used in Drug Abuse Prevention and Treatment:
Due to its high potential for abuse and the risk of fatal overdoses, N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride plays a significant role in drug abuse prevention and treatment programs. It is used to study the mechanisms of addiction, develop new treatment strategies, and improve the understanding of the risks associated with opioid use.
Used in Regulatory Compliance:
As a Schedule II compound, N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride is subject to strict regulatory controls. It is used in the development and enforcement of regulations aimed at preventing the diversion of opioids for illicit purposes and ensuring that these medications are used safely and responsibly in medical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 1443-54-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,4 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1443-54:
(6*1)+(5*4)+(4*4)+(3*3)+(2*5)+(1*4)=65
65 % 10 = 5
So 1443-54-5 is a valid CAS Registry Number.
InChI:InChI=1/C22H28N2O.ClH/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19;/h3-12,21H,2,13-18H2,1H3;1H
1443-54-5Relevant articles and documents
Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE)
Robertson, Thomas B. R.,Antonides, Lysbeth H.,Gilbert, Nicolas,Benjamin, Sophie L.,Langley, Stuart K.,Munro, Lindsey J.,Sutcliffe, Oliver B.,Mewis, Ryan E.
, p. 1375 - 1382 (2019/11/16)
Fentanyl, also known as ‘jackpot’, is a synthetic opiate that is 50–100 times more potent than morphine. Clandestine laboratories produce analogues of fentanyl, known as fentalogues to circumvent legislation regarding its production. Three pyridyl fentalogues were synthesized and then hyperpolarized by signal amplification by reversible exchange (SABRE) to appraise the forensic potential of the technique. A maximum enhancement of -168-fold at 1.4 T was recorded for the ortho pyridyl 1H nuclei. Studies of the activation parameters for the three fentalogues revealed that the ratio of ligand loss trans to hydride and hydride loss in the complex [Ir(IMes)(L)3(H)2]+ (IMes=1,3-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene) ranged from 0.52 to 1.83. The fentalogue possessing the ratio closest to unity produced the largest enhancement subsequent to performing SABRE at earth's magnetic field. It was possible to hyperpolarize a pyridyl fentalogue selectively from a matrix that consisted largely of heroin (97 : 3 heroin:fentalogue) to validate the use of SABRE as a forensic tool.
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