1443039-72-2Relevant articles and documents
Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds
Joyard, Yoann,Azzouz, Rabah,Bischoff, Laurent,Papamica?l, Cyril,Labar, Daniel,Bol, Anne,Bol, Vanessa,Vera, Pierre,Grégoire, Vincent,Levacher, Vincent,Bohn, Pierre
, p. 3680 - 3688 (2013/07/19)
The syntheses of new nitroimidazole compounds using silicon-[ 18F]fluorine chemistry for the potential detection of tumor hypoxia are described. [18F]silicon-based compounds were synthesized by coupling 2-nitroimidazole with silyldinaphtyl or silylphenyldi-tert-butyl groups and labeled by fluorolysis or isotopic exchange. Dinaphtyl compounds (6, 10) were labeled in 56-71% yield with a specific activity of 45 GBq/μmol, however these compounds ([18F]7 and [18F]11) were not stable in plasma. Phenyldi-tert-butyl compounds were labeled in 70% yield with a specific activity of 3 GBq/μmol by isotopic exchange, or in 81% yield by fluorolysis of siloxanes with a specific activity of 45 GBq/μmol. The labeled compound [18F]18 was stable in plasma and excreted by the liver and kidneys in vivo. In conclusion, the fluorosilylphenyldi-tert-butyl (SiFA) group is more stable in plasma than fluorosilyldiphenyl moiety. Thus, compound [ 18F]18 is suitable for further in vivo assessments.
