1443225-50-0

Basic information

• Product Name: (1-((5-chlorothiophen-2-yl)methyl)-1H-1,2,3-triazol-4-yl)(2,4-dichlorophenyl)methanone
• Synonyms: (1-((5-chlorothiophen-2-yl)methyl)-1H-1,2,3-triazol-4-yl)(2,4-dichlorophenyl)methanone
• CAS NO: 1443225-50-0
• Molecular Weight: 372.662
• Mol File: 1443225-50-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1-((5-chlorothiophen-2-yl)methyl)-1H-1,2,3-triazol-4-yl)(2,4-dichlorophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1-((5-chlorothiophen-2-yl)methyl)-1H-1,2,3-triazol-4-yl)(2,4-dichlorophenyl)methanone(1443225-50-0)
• EPA Substance Registry System: (1-((5-chlorothiophen-2-yl)methyl)-1H-1,2,3-triazol-4-yl)(2,4-dichlorophenyl)methanone(1443225-50-0)

Safety Data

• Hazardous Substances Data: 1443225-50-0(Hazardous Substances Data)

Upstream product

• 23784-96-5 2-Chloro-5-(chloromethyl)thiophene 
• 29805-13-8 1-(2',4'-dichlorophenyl)prop-2-yn-1-ol 

Relevant articles and documents

Copper-catalyzed huisgen 1,3-dipolar cycloaddition under oxidative conditions: Polymer-assisted assembly of 4-acyl-1-substituted-1,2,3-triazoles

We herein document the first example of a reliable copper-catalyzed Huisgen 1,3-dipolar cycloaddition under oxidative conditions. The combined use of two polymer-supported reagents (polystyrene-1,5,7-triazabicyclo[4,4,0]dec-5-ene/Cu and polystyrene-2-iodoxybenzamide) overcomes the thermodynamic instability of copper(I) species toward oxidation, enabling the reliable Cu-catalyzed Huisgen 1,3-dipolar cycloadditions in the presence of an oxidant agent. This polymer-assisted pathway, not feasible under conventional homogeneous conditions, provides a direct assembly of 4-acyl-1-substituted-1,2,3-triazoles, contributing to expand the reliability and scope of Cu(I)-catalyzed alkyne-azide cycloaddition.