144340-21-6

Basic information

• Product Name: 1H-Indole-5-carbonitrile, 1-(phenylsulfonyl)-
• CAS NO: 144340-21-6
• Molecular Formula: C15H10N2O2S
• Molecular Weight: 282.323
• Mol File: 144340-21-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Indole-5-carbonitrile, 1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-5-carbonitrile, 1-(phenylsulfonyl)-(144340-21-6)
• EPA Substance Registry System: 1H-Indole-5-carbonitrile, 1-(phenylsulfonyl)-(144340-21-6)

Safety Data

• Hazardous Substances Data: 144340-21-6(Hazardous Substances Data)

Usage

Structure

A derivative of indole with a phenylsulfonyl group attached to the nitrogen atom of the indole ring

Potential applications

Pharmaceutical, agrochemical, and materials science fields

Usage

Building block for the synthesis of biologically active molecules and agrochemicals, precursor for the development of new materials with specific properties and applications.

Upstream product

• 15861-24-2 1H-indole-5-carbonitrile 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 179748-01-7 1-Benzenesulfonyl-2-(2-fluoro-benzyl)-1H-indole-5-carbonitrile 
• 1235976-75-6 C₁₇H₁₂N₂O₃S 
• 1401726-53-1 (S)-2-methylpropane-2-sulfinic acid [(S)-1-(1-benzenesulfonyl-2-methyl-1H-indol-5-yl)-2,2,2-trifluoroethyl]amide 
• 36798-25-1 5-Aminomethyl-2-methylindol 
• 1401726-63-3 1-benzenesulfonyl-2-methyl-d3-1H-indole-5-carbonitrile 
• 1401726-51-9 1-benzenesulfonyl-2-methyl-1H-indole-5-carbaldehyde 
• 36798-24-0 2-methyl-1H-indole-5-carbonitrile 
• 1206725-52-1 3-(2-benzyl-1H-indol-5-yl)-2-(2,2,2-trifluoroethoxy)propanoic acid 
• 1206726-41-1 methyl 3-(2-benzyl-1H-indol-5-yl)-2-(2,2,2-trifluoroethoxy)propanoate 
• 1206726-36-4 (E)-ethyl 3-(2-benzyl-1H-indol-5-yl)-2-(2,2,2-trifluoroethoxy)acrylate 
• 1206726-31-9 (Z)-ethyl 3-(2-benzyl-1H-indol-5-yl)-2-(2,2,2-trifluoroethoxy)acrylate 
• 1206725-47-4 3-(2-benzyl-1H-indol-5-yl)-2-ethoxy-propanoic acid 
• 1206726-26-2 methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate 
• 182187-43-5 2-benzyl-1H-indole-5-carbaldehyde 

Relevant articles and documents

A Palladium(II)-Catalyzed C-H Activation Cascade Sequence for Polyheterocycle Formation

Polyheterocycles are found in many natural products and are useful moieties in functional materials and drug design. As part of a program towards the synthesis of Stemona alkaloids, a novel palladium(II)-catalyzed C-H activation strategy for the construction of such systems has been developed. Starting from simple 1,3-dienyl-substituted heterocycles, a large range of polycyclic systems containing pyrrole, indole, furan and thiophene moieties can be synthesized in a single step. Don't overdo it: A palladium(II)-catalyzed C-H activation cascade sequence for the synthesis of polyheterocycles is reported. Aromatization of the initially formed dihydro species occurred with a quinone oxidant. In some cases the use of one equivalent of the oxidant enabled isolation of the dihydro species as a single isomer (see scheme; X=NMe, O, S).

Synthesis and quantitative structure-activity relationship (QSAR) study of novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives as nematicidal agents

In continuation of our program aimed at the discovery and development of natural-product-based pesticidal agents, 54 novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives were prepared, and their structures were well characterized by 1

Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program PROTOBUILD

Peroxisome proliferator activated receptors (PPARs) have been shown to have critical roles in fatty acid oxidation, triglyceride synthesis, and lipid metabolism - making them an important target in drug discovery. Here we describe the in silico design, sy