144432-72-4

Basic information

• Product Name: 2-BENZYL-[1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE
• Synonyms: 2-BENZYL-[1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE
• CAS NO: 144432-72-4
• Molecular Formula: C₉H₁₂N₂O₂S
• Molecular Weight: 212.26878
• Mol File: 144432-72-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 39-46°
• Boiling Point: 361.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.321±0.06 g/cm3(Predicted)
• PKA: 13.16±0.20(Predicted)
• CAS DataBase Reference: 2-BENZYL-[1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-[1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE(144432-72-4)
• EPA Substance Registry System: 2-BENZYL-[1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE(144432-72-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 144432-72-4(Hazardous Substances Data)

Usage

Description

2-Benzyl-[1,2,5]thiadiazolidine 1,1-dioxide is an organic compound with a unique chemical structure that features a thiadiazolidine ring and a benzyl group. It is known for its potential applications in various chemical reactions and synthesis processes.

Uses

Used in Pharmaceutical Industry:
2-Benzyl-[1,2,5]thiadiazolidine 1,1-dioxide is used as a reactant for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides. These compounds are essential in the development of new pharmaceuticals, particularly in the synthesis of complex molecules with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Benzyl-[1,2,5]thiadiazolidine 1,1-dioxide serves as a versatile building block for creating a wide range of chemical compounds. Its unique structure allows for various functional group transformations and reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Research and Development:
2-Benzyl-[1,2,5]thiadiazolidine 1,1-dioxide is also utilized in research and development settings, where it can be employed to study the properties and reactivity of thiadiazolidine-containing compounds. This can lead to a better understanding of their potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 4152-09-4 N-benzylethylenediamine 
• 503310-46-1 5-benzyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidine-2-carboxylic acid methyl ester 
• 182925-65-1 N-(2-chloroethyl)-N'-benzylsulfamide 
• 263719-86-4 N²-BOC-N⁵-benzyl-1,2,5-thiadiazolidine 1,1-dioxide 
• 104-63-2 N-Benzylethanolamine 
• 147000-78-0 N¹-BOC-N³-benzylsulfamide 
• 7803-58-9 SULFAMIDE 

Downstream Products

• 603132-93-0 (5-benzyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-2-yl)-acetic acid tert-butyl ester 
• 1375260-87-9 C₁₂H₁₆N₂O₄S 
• 1375263-05-0 C₁₃H₁₈N₂O₄S 
• 1375263-16-3 C₁₄H₂₀N₂O₄S 
• 1261242-18-5 C₁₉H₂₃N₃O₄S 
• 1261242-21-0 C₁₁H₁₇N₃O₂S 
• 1261242-39-0 C₂₆H₂₄FN₇O₂S₂ 
• 5823-51-8 1,2,5-thiadiazolidine 1,1-dioxide 
• 1092980-93-2 C₁₅H₁₄FN₃O₄S 
• 144432-39-3 3-(2-aminoethyl)-5-(5-benzyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)-1H-indole 
• 786612-48-4 [4-(5-Benzyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-2-yl)-phenyl]-hydrazine 
• 144432-73-5 4-(5-Benzyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)nitrobenzene 

Relevant articles and documents

A new method for the synthesis of nonsymmetrical sulfamides using Burgess-type reagents

A practical and high-yielding method for the efficient, one-step synthesis of diverse classes of N,N′-differentiated sulfamides has been developed from a wide range of amino alcohols and simple amines using Burgess-type reagents (see scheme). This method

Discovery of New Imidazo[2,1- b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising in Vitro and in Vivo Anti-melanoma Activity

BRAF is an important component of MAPK cascade. Mutation of BRAF, in particular V600E, leads to hyperactivation of the MAPK pathway and uncontrolled cellular growth. Resistance to selective inhibitors of mutated BRAF is a major obstacle against treatment of many cancer types. In this work, a series of new (imidazo[2,1-b]thiazol-5-yl)pyrimidine derivatives possessing a terminal sulfonamide moiety were synthesized. Pan-RAF inhibitory effect of the new series was investigated, and structure-activity relationship is discussed. Antiproliferative activity of the target compounds was tested against the NCI-60 cell line panel. The most active compounds were further tested to obtain their IC50 values against cancer cells. Compound 27c with terminal open chain sulfonamide and 38a with a cyclic sulfamide moiety showed the highest activity in enzymatic and cellular assay, and both compounds were able to inhibit phosphorylation of MEK and ERK. Compound 38a was selected for testing its in vivo activity against melanoma. Cellular and animal activities are reported.

A kind of IDO inhibitor and use thereof

The embodiment of the invention provides general formula (I) compound or its pharmaceutically acceptable salts, stereoisomers, a tautomeric form each other, polymorphs, solvate, prodrug, metabolite or isotope derivatives, wherein the substituents R1

Aromatic polycyclic carboxylic acid derivatives

The invention specifically relates to aromatic polycyclic carboxylic acid derivative GPR40 receptor agonists as shown in a general formula (I) which is described in the specification, and pharmaceutically acceptable salts, esters or stereoisomers thereof,