1444335-43-6

Basic information

• Product Name: 5-(benzyloxy)-N-(3-((5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl)oxy)propyl)-3,4,6-trimethylpyridin-2-amine
• Synonyms: 5-(benzyloxy)-N-(3-((5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl)oxy)propyl)-3,4,6-trimethylpyridin-2-amine
• CAS NO: 1444335-43-6
• Molecular Weight: 525.691
• Mol File: 1444335-43-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(benzyloxy)-N-(3-((5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl)oxy)propyl)-3,4,6-trimethylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-N-(3-((5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl)oxy)propyl)-3,4,6-trimethylpyridin-2-amine(1444335-43-6)
• EPA Substance Registry System: 5-(benzyloxy)-N-(3-((5-(benzyloxy)-3,4,6-trimethylpyridin-2-yl)oxy)propyl)-3,4,6-trimethylpyridin-2-amine(1444335-43-6)

Safety Data

• Hazardous Substances Data: 1444335-43-6(Hazardous Substances Data)

Upstream product

• 1444336-77-9 3-(benzyloxy)-6-bromo-2,4,5-trimethylpyridine 
• 156-87-6 propan-1-ol-3-amine 
• 1444336-68-8 6-bromo-2,4,5-trimethylpyridine-3-ol 
• 5622-78-6 2,4,5-trimethylpyridine-3-ol 
• 39984-50-4 4,5-bis(chloromethyl)-3-hydroxy-2-methylpyridinium chloride 
• 58-56-0 pyridoxal hydrochloride 

Relevant articles and documents

6-Amino-2,4,5-trimethylpyridin-3-ols: A new general synthetic route and antiangiogenic activity

A new synthetic strategy for preparation of a wide range of 6-amino-2,4,5-trimethylpyridin-3-ols from pyridoxine·HCl via a six-step sequence has been developed. This approach features an introduction of various amino groups to C(6)-position of 3-benzyloxy-6-bromo-2,4,5-trimethylpyridine (13), a key intermediate, by a Buchwald-Hartwig amination reaction using palladium(0) transition metal, which certainly renders an expanded scope of amino substituents. Some analogs prepared using the methods described here showed high level of antiangiogenic and antitumor activities in chick chorioallantoic membrane (CAM) assay, demonstrating the potential of these new aminopyridinols as antiangiogenic agents.