144464-53-9

Basic information

• Product Name: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(2-chlorophenyl)-
• CAS NO: 144464-53-9
• Molecular Formula: C20H13ClN2O
• Molecular Weight: 332.789
• Mol File: 144464-53-9.mol
• Article Data: 41

Chemical Properties

• CAS DataBase Reference: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(2-chlorophenyl)-(144464-53-9)
• EPA Substance Registry System: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(2-chlorophenyl)-(144464-53-9)

Safety Data

• Hazardous Substances Data: 144464-53-9(Hazardous Substances Data)

Upstream product

• 90-15-3 α-naphthol 
• 2698-41-1 o-chlorobenzylidene malononitrile 
• 89-98-5 2-chloro-benzaldehyde 
• 109-77-3 malononitrile 
• 17849-38-6 2-Chlorobenzyl alcohol 

Downstream Products

• 1446242-87-0 4-(2-chlorophenyl)-2-oxo-2H-benzo[h]chromene-3-carbonitrile 
• 144464-57-3 8-Amino-7-(2-chloro-phenyl)-10-methyl-7H-12-oxa-11-aza-benzo[a]anthracene-9-carbonitrile 
• 1639461-45-2 2-(3-oxocyclohex-1-enylamino)-4-(2-chlorophenyl)-4H-benzo[h]chromene-3-carbonitrile 
• 1639461-49-6 C₂₆H₁₉ClN₂O₂ 

Relevant articles and documents

Choline chloride-coated UiO-66-Urea MOF: A novel multifunctional heterogeneous catalyst for efficient one-pot three-component synthesis of 2-amino-4H-chromenes

A new Zr-based MOF, namely, UiO-66-Urea, was prepared through polymerization between the 2-aminoterephthalate linkers of UiO-66-NH2 MOF and 1,4-phenylene diisocyanate under mild reaction conditions. Post-synthetic coating of UiO-66-Urea with ch

Organocatalytic Cascade Knoevenagel–Michael Addition Reactions: Direct Synthesis of Polysubstituted 2-Amino-4H-Chromene Derivatives

Abstract: In this report, we documented novel strategy for the synthesis of bioactive polysubstituted 2-amino-4H-chromine derivatives under a heterogeneous Al-MCM-41-LDH@APTES (ALAM) catalysis. A synthetic procedure is developed to prepare Al-MCM-41-LDH@APTES (ALAM) heterogeneous basic catalysts. Mesoporous Al-MCM-41 is functionalized by known grafting chemistry via layered double hydroxide (LDH) nanosheets and (3-aminopropyl)triethoxysilane (APTES) moiety as a basic organocatalyst. The resulting catalysts contain amino group functionality on the external surface as well as inside the layers and the basicity can be tuned by the loading of APTES. The samples were fully characterized by 29Si and 13C CP/MAS NMR, infrared absorption spectroscopy, TEM, XPS, EDX, TGA, XRD, CO2-TPD, N2 adsorption isotherms measurements, and they were successfully examined for the cascade type Knoevenagel–Michael addition reactions. The product yields associated with these substrates were optimized, and key reaction parameters affecting the yields were identified. The present catalytic method is simple and robust for diversity oriented synthesis which proceeds good to excellent yields without generating any hazards waste. The broad substrate scope, excellent functional group compatibility makes this protocol highly useful towards synthesis of polysubstituted α-cyanoacrylates, α-cyanoacrylonitriles and 2-amino-4H-chromenes with an electron-donating or electron-withdrawing group. We have also successfully established a flow reaction system, gram-scale synthesis as well as catalyst recyclability up to six catalytic cycles without appreciable loss of its activity. Graphic Abstract: [Figure not available: see fulltext.].

One-pot Synthesis of 2-Amino-4H-Chromenes using Chicken Eggshell Waste as Green Catalyst under Solvent-Free Conditions

Chicken eggshell waste has been employed as green and efficient catalyst for the preparation of 2-amino-4H-chromenes. The aromatic aldehydes were condensed with malononitrile and 1-naphthol or 2-naphthol under solvent-free condition in the presence of chi