1444877-86-4

Basic information

• Product Name: 1-(4-bromophenyl)-N-(3-tert-butoxybenzyl)-N-methylmethanamine
• Synonyms: 1-(4-bromophenyl)-N-(3-tert-butoxybenzyl)-N-methylmethanamine
• CAS NO: 1444877-86-4
• Molecular Weight: 362.31
• Mol File: 1444877-86-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-bromophenyl)-N-(3-tert-butoxybenzyl)-N-methylmethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-N-(3-tert-butoxybenzyl)-N-methylmethanamine(1444877-86-4)
• EPA Substance Registry System: 1-(4-bromophenyl)-N-(3-tert-butoxybenzyl)-N-methylmethanamine(1444877-86-4)

Safety Data

• Hazardous Substances Data: 1444877-86-4(Hazardous Substances Data)

Upstream product

• 699-03-6 N-methyl-4-bromobenzylamine 
• 100-83-4 meta-hydroxybenzaldehyde 
• 1444877-76-2 3-[N-(4-bromobenzyl)-N-methylaminomethyl]phenol 
• 157634-00-9 tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate 

Relevant articles and documents

Conversion of phenols into aryl tert-butyl ethers under mitsunobu conditions utilizing neighboring group contribution

Under Mitsunobu conditions N-Boc-2-(hydroxymethyl)piperidine acts as a source of tert-butyl residue for the conversion of phenols into aryl tert-butyl ethers under neutral conditions. This reactivity can be attributed to a neighboring group contribution which strongly depends on the structure of the employed N-Boc-aminoalcohol. Five other, closely related N-Boc-aminoalcohols investigated here did not show this special reactivity, and gave the regular Mitsunobu coupling products.