144493-15-2

Basic information

• Product Name: Benzoic acid, 4-(1-octynyl)-, methyl ester
• CAS NO: 144493-15-2
• Molecular Formula: C16H20O2
• Molecular Weight: 244.334
• Mol File: 144493-15-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(1-octynyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(1-octynyl)-, methyl ester(144493-15-2)
• EPA Substance Registry System: Benzoic acid, 4-(1-octynyl)-, methyl ester(144493-15-2)

Safety Data

• Hazardous Substances Data: 144493-15-2(Hazardous Substances Data)

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 68113-72-4 1-octynylzinc chloride 
• 629-05-0 n-octyne 
• 619-58-9 4-iodobenzoic acid 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 54256-51-8 4-octyl-benzoic acid methyl ester 
• 3575-31-3 4-octylbenzoic acid 
• 50606-97-8 p-n-octylbenzoyl chloride 
• 144492-91-1 Methyl (E)-4-(2-hexyl-3-hydroxy-5-phenyl-1-pentenyl)benzoate 
• 144493-06-1 Methyl (E)-4-(1-heptylidene-2-hydroxy-4-phenylbutyl)benzoate 

Relevant articles and documents

Binuclear Pd(I)-Pd(I) Catalysis Assisted by Iodide Ligands for Selective Hydroformylation of Alkenes and Alkynes

Since its discovery in 1938, hydroformylation has been thoroughly investigated and broadly applied in industry (>107 metric ton yearly). However, the ability to precisely control its regioselectivity with well-established Rh- or Co-catalysts has thus far proven elusive, thereby limiting access to many synthetically valuable aldehydes. Pd-catalysts represent an appealing alternative, yet their use remains sparse due to undesired side-processes. Here, we report a highly selective and exceptionally active catalyst system that is driven by a novel activation strategy and features a unique Pd(I)-Pd(I) mechanism, involving an iodide-assisted binuclear step to release the product. This method enables β-selective hydroformylation of a large range of alkenes and alkynes, including sensitive starting materials. Its utility is demonstrated in the synthesis of antiobesity drug Rimonabant and anti-HIV agent PNU-32945. In a broader context, the new mechanistic understanding enables the development of other carbonylation reactions of high importance to chemical industry.

Aqueous Sonogashira coupling of aryl halides with 1-alkynes under mild conditions: Use of surfactants in cross-coupling reactions

Aqueous Sonogashira coupling between lipophilic terminal alkynes and aryl bromides or iodides gave moderate to high yields at 40°C using readily available and inexpensive surfactants (2.0 w/v% in water) such as SDS and CTAB. The catalyst precursor was 2 m

Improved palladium-catalyzed sonogashira coupling reactions of aryl chlorides

The improved palladium-catalyzed Sonogashira coupling reactions of aryl chlorides without the necessity to add copper salts were analyzed for the development of palladacycles, adamantylphosphines, carhene ligands, and 2-phosphino-N-arylin-doles and -pyrro