144499-11-6

Basic information

• Product Name: Acetic acid, trifluoro-, 1-cyano-4-phenyl-1-(2-pyridinylthio)butyl ester
• CAS NO: 144499-11-6
• Molecular Formula: C18H15F3N2O2S
• Molecular Weight: 380.391
• Mol File: 144499-11-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetic acid, trifluoro-, 1-cyano-4-phenyl-1-(2-pyridinylthio)butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, trifluoro-, 1-cyano-4-phenyl-1-(2-pyridinylthio)butyl ester(144499-11-6)
• EPA Substance Registry System: Acetic acid, trifluoro-, 1-cyano-4-phenyl-1-(2-pyridinylthio)butyl ester(144499-11-6)

Safety Data

• Hazardous Substances Data: 144499-11-6(Hazardous Substances Data)

Upstream product

• 1121-30-8 1-hydroxy-2(1H)-pyridinethione 
• 400-55-5 α-trifluoroacetyoxy acrylonitrile 
• 114050-31-6 3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 

Downstream Products

• 10031-93-3 ethyl 4-phenylbutyrate 
• 1821-12-1 4-Phenylbutyric acid 

Relevant articles and documents

The Invention of Radical Reactions. XXXIII Homologation Reactions of Carboxylic Acids by Radical Chain Chemistry

Various carbon radicals can be generated from carboxylic acids via the corresponding Barton esters.These radicals can be used for the synthesis of longer chain homologues of the original acids.

Homologation of carboxylic acids by improved methods based on radical chain chemistry of acyl derivatives of N-hydroxy-2-thiopyridone

Reaction of substituted terminal olefins with carbon radicals generated carboxylic acids gives adducts that can be transformed to one carbon atom longer homo-acids in high overall yield. With 6b yields are very good and the conditions of hydrolysis exceptionally mild.