14452-34-7Relevant articles and documents
Nitration of phenolic compounds by antimony nitrate
Jirandehi, Hassan Fathinejad,Mirzaeian, Marjan
, p. 284 - 286 (2011)
Antimony nitrate is new compound to be an efficient nitration reagent in the nitration of phenolic compounds with high yields. This producerworks efficiently onmost of the examples, as a grinding nitration reaction, proceed very fast (~1 min) and thermogenic. Copyright Taylor & Francis Group, LLC.
Synthesis of new carbon-11 labeled benzoxazole derivatives for PET imaging of 5-HT3 receptor
Gao, Mingzhang,Wang, Min,Hutchins, Gary D.,Zheng, Qi-Huang
, p. 1570 - 1574 (2008/09/21)
5-HT3 receptor is an attractive target for the development of therapeutic agents for use in brain, heart and cancer diseases, and imaging agents for use in biomedical imaging technique PET. Benzoxazole derivatives are a novel class of 5-HT3 receptor partial agonists with high binding affinity. Carbon-11 labeled benzoxazole derivatives have been synthesized as new potential PET radioligands for imaging 5-HT3 receptor. The target tracers were prepared by N-[11C]methylation of their corresponding precursors using [11C]CH3OTf and isolated by HPLC purification procedure in 40-50% radiochemical yields, which were decay corrected to the end of bombardment (EOB), based on [11C]CO2. The overall synthesis time was 20-25 min from EOB. The radiochemical purity was >99%, and specific activity was in a range of 74-111 GBq/μmol at the end of synthesis (EOS).
15N Nuclear Polarisation in Nitration and Related Reactions. Part 7. The Mechanisms of Rearrangement of 4-Methyl-4-nitrocyclohexa-2,5-dienones
Ridd, John H.,Trevellick, Susan,Sandall, John P. B.
, p. 1535 - 1540 (2007/10/02)
The rearrangement of 4-methyl-4-nitrocyclohexa-2,5-dienone to 4-methyl-2-nitrophenol has been studied in acetic anhydride at 22-37.5 deg C in the presence of varying concentrations of sulfuric acid.Similar studies have been carried out on the 15N labelled compound and on the effects of some substituents (2-Me, 3-Me, 2-NO2).During reaction, the thermal rearrangement of the labelled compound gives very strongly enhanced 15N NMR absorption signals (enhancement coefficient ca. 1000) for both the substrate and the product.For acid catalysed reaction, the enhancement coefficient of the signals is less (ca. 130) but still sufficient to indicate a homolytic reaction path.This interpretation is shown to be consistent with the properties of the radicals involved and with the substituent effects observed.