1445218-36-9

Basic information

• Product Name: 5-(3-fluoro-4-trifluoromethyl-phenyl)-oxazole
• Synonyms: 5-(3-fluoro-4-trifluoromethyl-phenyl)-oxazole
• CAS NO: 1445218-36-9
• Molecular Weight: 231.149
• Mol File: 1445218-36-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 5-(3-fluoro-4-trifluoromethyl-phenyl)-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-fluoro-4-trifluoromethyl-phenyl)-oxazole(1445218-36-9)
• EPA Substance Registry System: 5-(3-fluoro-4-trifluoromethyl-phenyl)-oxazole(1445218-36-9)

Safety Data

• Hazardous Substances Data: 1445218-36-9(Hazardous Substances Data)

Upstream product

• 204339-72-0 3-fluoro-4-trifluoromethyl-benzaldehyde 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 

Downstream Products

• 1445218-26-7 4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine 
• 1469979-58-5 (rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol 
• 1469979-93-8 4-(3-fluoro-4-trifluoromethylphenyl)-5,6-dihydro-7H-cyclopenta[c]pyridin-7-one 
• 1552274-20-0 1-cyclopropylmethyl-5-(3-fluoro-4-trifluoromethylphenyl)-1H-imidazole 
• 1552274-06-2 1-[2-(4-fluorophenyl)ethyl]-5-(3-fluoro-4-trifluoromethylphenyl)-1H-imidazole 
• 1552273-85-4 1-(cyclopent-3-en-1-yl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)-1H-imidazole 

Relevant articles and documents

INHIBITOR COMPOUNDS

The disclosure relates to heterocyclic compounds and methods for their preparation. The disclosure provides compounds that may have beneficial therapeutic activity in the treatment of a disease or condition mediated by excessive or otherwise undesirable Des1 and/or fibrotic activity.

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

A series of cyclopenta[c]pyridine aldosterone synthase (AS) inhibitors were conveniently accessed using batch or continuous flow Kondrat'eva reactions. Preparation of the analogous cyclohexa[c]pyridines led to the identification of a potent and more selective AS inhibitor. The structure-activity-relationship (SAR) in this new series was rationalized using binding mode models in the crystal structure of AS.

NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds in the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrom.