144527-44-6

Basic information

• Product Name: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride
• Synonyms: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride;1-tert-Butyl 2-Methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxy
• CAS NO: 144527-44-6
• Molecular Formula: C₁₁H₁₉NO₅*ClH
• Molecular Weight: 281.7332
• Mol File: 144527-44-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride(144527-44-6)
• EPA Substance Registry System: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride(144527-44-6)

Safety Data

• Hazardous Substances Data: 144527-44-6(Hazardous Substances Data)

Usage

General Description

(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride is a chemical compound with the molecular formula C12H23NO5Cl. It is a derivative of the amino acid proline and is commonly used in the synthesis of pharmaceutical compounds and as a building block in organic synthesis. The compound is a white solid that is soluble in water and is typically used in research and development settings for its ability to modify and enhance the properties of other organic molecules. Additionally, it is known for its potential pharmacological activity and may have applications in drug discovery and development. (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride is also known by its chemical name tert-butyl (2S,4R)-4-hydroxy-1,2-pyrrolidine-1,2-dicarboxylate hydrochloride.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 88043-21-4 (2S,4R)-4-(toluene-4-sulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 114676-48-1 (2S,4R)-1-benzyl-4-hydroxyproline methyl ester 
• 154429-40-0 (2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Efficient α-helix induction in a linear peptide chain by n-capping with a bridged-tricyclic diproline analogue

Secondary structure induction: The synthetic tricyclic amino acid ProM-5, which is formally created by stereoselective introduction of a vinylidene bridge into a di-proline unit, acts as a powerful scaffold to nucleate α-helix formation in a linear peptide chain. This might be exploited in the development of new proteomimetics for the modulation of protein interactions. Copyright