1445768-34-2

Basic information

• Product Name: 1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(4-(4-hydroxy-8-nitroquinazolin-5-ylamino)cyclohexyl)urea
• CAS NO: 1445768-34-2
• Molecular Weight: 524.887
• Mol File: 1445768-34-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(4-(4-hydroxy-8-nitroquinazolin-5-ylamino)cyclohexyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(4-(4-hydroxy-8-nitroquinazolin-5-ylamino)cyclohexyl)urea(1445768-34-2)
• EPA Substance Registry System: 1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(4-(4-hydroxy-8-nitroquinazolin-5-ylamino)cyclohexyl)urea(1445768-34-2)

Safety Data

• Hazardous Substances Data: 1445768-34-2(Hazardous Substances Data)

Upstream product

• 1445768-29-5 tert-butyl 4-(3-(2-chloro-5-(trifluoromethyl)phenyl)ureido)cyclohexylcarbamate 
• 3114-70-3 trans-1,4-diaminocyclohexane 
• 400784-50-1 4-hydroxy-5-chloro-8-nitro-quinazoline 
• 1445768-08-0 C₁₄H₁₇ClF₃N₃O 
• 50528-86-4 2-chloro-5-(trifluoromethyl)phenyl isocyanate 
• 195314-59-1 tert-butyl (4-aminocyclohexyl)carbamate 

Relevant articles and documents

Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase: Synthesis, biological evaluation and molecular docking

Vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibition is a well-established strategy to promptly tackle tumor growth by suppression of angiogenesis. We report herein a series of 5-anilinoquinazoline derivatives substituted by 1,3-disubstituted urea. All the newly synthesized compounds described were evaluated for VEGFR-2 kinase inhibition and antiproliferative activity against various cancer cells. The novel 1-aryl, 3-aryl-disubstituted urea quinazolines were effective VEGFR-2 kinase inhibitors with in vitro IC 50 values in the submicromolar range (compound 6f, IC50 12.0 nM), but showed a weak to moderate inhibitory activity on cancer cells. Molecular interactions of the compounds were studied using molecular docking studies. The Royal Society of Chemistry 2013.