1446210-70-3

Basic information

• Product Name: N-{[1-(3-formyl-4-hydroxybenzyl)-1H-1,2,3-triazol-4-yl]methyl}-3α,12α-dihydroxy-5β-cholan-24-amide
• Synonyms: N-{[1-(3-formyl-4-hydroxybenzyl)-1H-1,2,3-triazol-4-yl]methyl}-3α,12α-dihydroxy-5β-cholan-24-amide
• CAS NO: 1446210-70-3
• Molecular Weight: 606.806
• Mol File: 1446210-70-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{[1-(3-formyl-4-hydroxybenzyl)-1H-1,2,3-triazol-4-yl]methyl}-3α,12α-dihydroxy-5β-cholan-24-amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{[1-(3-formyl-4-hydroxybenzyl)-1H-1,2,3-triazol-4-yl]methyl}-3α,12α-dihydroxy-5β-cholan-24-amide(1446210-70-3)
• EPA Substance Registry System: N-{[1-(3-formyl-4-hydroxybenzyl)-1H-1,2,3-triazol-4-yl]methyl}-3α,12α-dihydroxy-5β-cholan-24-amide(1446210-70-3)

Safety Data

• Hazardous Substances Data: 1446210-70-3(Hazardous Substances Data)

Upstream product

• 1024746-93-7 (4R)-4-((3R,10S,12S,13R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N-(prop-2-yn-1-yl)pentanamide 
• 714916-55-9 5-(azidomethyl)-2-hydroxybenzaldehyde 

Relevant articles and documents

A zinc-salophen/bile-acid conjugate receptor solubilized by CTABr micelles binds phosphate in water

Receptor 1, composed of two deoxycholic acid moieties appended to a Zn-salophen complex, was prepared, characterized and tested for anion binding by 1H NMR and UV-vis spectroscopic techniques. While in polar DMSO, 1 is able to bind phosphate (K = ～700 M-1), the addition of water severely diminishes the association. In a 1: 9 water-DMSO mixture, the binding constant K is only ca. 20 M-1. Notably, in an aqueous solution of CTABr micelles (CTABr 10 mM, cmc = ～1 mM), the zinc-salophen conjugate 1, due to its two non-polar bile-acid moieties, becomes solubilized and, most importantly, it almost completely recovers its binding ability towards phosphate, displaying a remarkable affinity (K = ～450 M-1) in water. is