1446238-96-5

Basic information

• Product Name: (R)-2-((S)-6,7-dimethoxy-1-(4-(trifluoromethyl)styryl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• CAS NO: 1446238-96-5
• Molecular Weight: 510.556
• Mol File: 1446238-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-((S)-6,7-dimethoxy-1-(4-(trifluoromethyl)styryl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-((S)-6,7-dimethoxy-1-(4-(trifluoromethyl)styryl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide(1446238-96-5)
• EPA Substance Registry System: (R)-2-((S)-6,7-dimethoxy-1-(4-(trifluoromethyl)styryl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide(1446238-96-5)

Safety Data

• Hazardous Substances Data: 1446238-96-5(Hazardous Substances Data)

Upstream product

• 871224-68-9 (S)-2-(methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate 

Relevant articles and documents

Enantioselective synthesis of almorexant via iridium-catalysed intramolecular allylic amidation

An enantioselective synthesis of almorexant, a potent antagonist of human orexin receptors, is presented. The chiral tetrahydroisoquinoline core structure was prepared via iridium-catalysed asymmetric intramolecular allylic amidation. Further key catalytic steps of the synthesis include an oxidative Heck reaction at room temperature and a hydrazine-mediated organocatalysed reduction. The Royal Society of Chemistry 2013.