1446354-68-2

Basic information

• Product Name: N-[(4-trifluoromethylphenyl)carbamothioyl]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• Synonyms: N-[(4-trifluoromethylphenyl)carbamothioyl]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• CAS NO: 1446354-68-2
• Molecular Weight: 584.566
• Mol File: 1446354-68-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[(4-trifluoromethylphenyl)carbamothioyl]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-trifluoromethylphenyl)carbamothioyl]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide(1446354-68-2)
• EPA Substance Registry System: N-[(4-trifluoromethylphenyl)carbamothioyl]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide(1446354-68-2)

Safety Data

• Hazardous Substances Data: 1446354-68-2(Hazardous Substances Data)

Upstream product

• 1645-65-4 4-(trifluoromethyl)phenyl isothiocyanate 
• 169590-42-5 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide 

Downstream Products

• 1446354-73-9 N-[3-(4-trifluoromethylphenyl)-4-oxo-1,3-thiazolidin-2-yldene]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 

Relevant articles and documents

Potent and selective HDAC6 inhibitory activity of N-(4- hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A

Eight N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes were efficiently prepared as sulfur analogues of Tubastatin A and thus evaluated as new HDAC6 inhibitors. All compounds exhibited potency against HDAC6, and four of them were active in the nanomolar range (IC50 = 1.9-22 nM). Further analysis revealed that the sulfone derivatives (designated as Tubathians) are superior to their non-oxidized sulfide analogues, and the two most active sulfones showed good to excellent HDAC6 selectivity compared to all other HDAC isoform classes.