1446715-71-4

Basic information

• Product Name: C₁₆H₁₂N₂OS
• CAS NO: 1446715-71-4
• Molecular Weight: 280.35
• Mol File: 1446715-71-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₂N₂OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₂N₂OS(1446715-71-4)
• EPA Substance Registry System: C₁₆H₁₂N₂OS(1446715-71-4)

Safety Data

• Hazardous Substances Data: 1446715-71-4(Hazardous Substances Data)

Upstream product

• 1446716-55-7 C₈H₇BrN₂OS 
• 536-74-3 phenylacetylene 
• 1446716-53-5 C₈H₉BrN₂O₂S 
• 1446716-51-3 C₁₀H₁₃BrN₂O₂S 
• 949019-55-0 ethyl-2-bromo-4-(bromomethyl)thiazole-5-carboxylate 
• 22900-83-0 ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate 

Relevant articles and documents

Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators

A new series of potent fused thiazole mGlu5 receptor positive allosteric modulators (PAMs) (10, 11 and 27-31) are disclosed and details of the SAR and optimization are described. Optimization of alkynyl thiazole 9 (Lu AF11205) led to the identification of potent fused thiazole analogs 10b, 27a, 28j and 31d. In general, substituted cycloalkyl, aryl and heteroaryl carboxamides, and carbamate analogs are mGlu5 PAMs, whereas smaller alkyl carboxamide, sulfonamide and sulfamide analogs tend to be mGlu5 negative allosteric modulators (NAMs).