1446750-92-0

Basic information

• Product Name: 4-[2-(2-bromophenyl)acetamidoethyl]benzenesulfonamide
• Synonyms: 4-[2-(2-bromophenyl)acetamidoethyl]benzenesulfonamide
• CAS NO: 1446750-92-0
• Molecular Weight: 397.293
• Mol File: 1446750-92-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[2-(2-bromophenyl)acetamidoethyl]benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(2-bromophenyl)acetamidoethyl]benzenesulfonamide(1446750-92-0)
• EPA Substance Registry System: 4-[2-(2-bromophenyl)acetamidoethyl]benzenesulfonamide(1446750-92-0)

Safety Data

• Hazardous Substances Data: 1446750-92-0(Hazardous Substances Data)

Upstream product

• 55116-09-1 2-bromophenylacetyl chloride 
• 35303-76-5 4-(2-aminoethyl)benzenesulfonamide 

Relevant articles and documents

A class of sulfonamides with strong inhibitory action against the α-carbonic anhydrase from trypanosoma cruzi

Trypanosoma cruzi, the causative agent of Chagas disease, encodes for an α-carbonic anhydrase (CA, EC 4.2.1.1) possessing high catalytic activity (TcCA) which was recently characterized (Pan et al. J. Med. Chem. 2013, 56, 1761-1771). A new class of sulfonamides possessing low nanomolar/subnanomolar TcCA inhibitory activity is described here. Aromatic/heterocyclic sulfonamides incorporating halogeno/methoxyphenacetamido tails inhibited TcCA with K Is in the range of 0.5-12.5 nM, being less effective against the human off-target isoforms hCA I and II. A homology model of TcCA helped us to rationalize the excellent inhibition profile of these compounds against the protozoan enzyme, a putative new antitrypanosoma drug target. These compounds were ineffective antitrypanosomal agents in vivo due to penetrability problems of these highly polar molecules that possess sulfonamide moieties.