144689-78-1

Basic information

• Product Name: Olmesartan
• Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID (5-METHYL-2-OXO-1,3-DIOXOL-4-YL)METHYL ESTER;Olmesartan;n-Butyl OlMesartan MedoxoMil;1H-Imidazole-5-carboxylic acid, 2-butyl-4-(1-hydroxy-1-methylethyl)-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-(2-hydroxypropan-2-yl)-1H-imidazole-5-carboxylate;MEDOXOMIL;2-butyl-4-(1-hydroxy-1-methylethyl)-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• CAS NO: 144689-78-1
• Molecular Formula: C₃₀H₃₂N₆O₆
• Molecular Weight: 446.5
• Product Categories: Cnbio
• Mol File: 144689-78-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 808.75 °C at 760 mmHg
• Flash Point: 442.916 °C
• Appearance: /
• Density: 1.36
• PKA: 4.15±0.10(Predicted)
• CAS DataBase Reference: Olmesartan(CAS DataBase Reference)
• NIST Chemistry Reference: Olmesartan(144689-78-1)
• EPA Substance Registry System: Olmesartan(144689-78-1)

Safety Data

• Hazardous Substances Data: 144689-78-1(Hazardous Substances Data)

Usage

Description

Olmesartan, also known as Olmesartan Medoxomil, is an angiotensin II receptor antagonist derived from hydrolyzable tannins found in various plant sources. It possesses properties that allow it to block the action of angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure. Its chemical structure enables interactions with the angiotensin II receptor, making it a promising pharmaceutical candidate for the treatment of hypertension.
Used in Pharmaceutical Industry:
Olmesartan is used as an anti-hypertensive agent for the treatment of hypertension. It works by selectively blocking the action of angiotensin II, a potent vasoconstrictor, which in turn reduces blood pressure and alleviates the symptoms associated with high blood pressure. This makes it a valuable drug for managing and controlling hypertension in patients.

InChI:InChI=1S/C30H32N6O6/c1-5-6-11-24-31-26(30(3,4)39)25(28(37)40-17-23-18(2)41-29(38)42-23)36(24)16-19-12-14-20(15-13-19)21-9-7-8-10-22(21)27-32-34-35-33-27/h7-10,12-15,39H,5-6,11,16-17H2,1-4H3,(H,32,33,34,35)

Relevant articles and documents

ANGIOTENSIN II ANTAGONIST 1-BIPHENYLMETHYLIMIDAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the following formula (I) or the formula (I) p : STR1 wherein R 1 is alkyl or alkenyl; R 2 and R 3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R 4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula--SiR a R b R c, in which R a, R b and R c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R 5 is carboxy or--CONR 8 R 9, wherein R 8 and R 9 hydrogens or alkyl, or R 8 and R 9 together form alkylene; R 6 is hydrogen, alkyl, alkoxy or halogen; R. sup.7 is carboxy or tetrazol-5-yl; R p. sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R p 2 is a single bond, alkylene or alkylidene; R p 3 and R p 4 are each hydrogen or alkyl; R. sub.p 6 is carboxy or tetrazol-5-yl; and X p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.