144690-85-7

Basic information

• Product Name: 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester
• CAS NO: 144690-85-7
• Molecular Formula: C30H36N2O6
• Molecular Weight: 520.626
• Mol File: 144690-85-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester(144690-85-7)
• EPA Substance Registry System: 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester(144690-85-7)

Safety Data

• Hazardous Substances Data: 144690-85-7(Hazardous Substances Data)

Upstream product

• 51802-42-7 2-propylimidazole-4,5-dicarbonitrile 
• 58954-23-7 2-propyl-1H-imidazole-4,5-dicarboxylic acid 
• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 144689-94-1 diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate 

Downstream Products

• 1026694-93-8 Oxalic acid 1-(2'-tert-butoxycarbonyl-biphenyl-4-ylmethyl)-5-ethoxycarbonyl-2-propyl-1H-imidazol-4-ylmethyl ester ethyl ester 
• 154237-87-3 1-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl-2-propyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 172876-05-0 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-methyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 154237-91-9 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 154237-82-8 4'-(4,5-Bis-hydroxymethyl-2-propyl-imidazol-1-ylmethyl)-biphenyl-2-carboxylic acid tert-butyl ester 
• 172876-10-7 ethyl 1-<(2'-carboxybiphenyl-4-yl)methyl>-4-methyl-2-propylimidazole-5-carboxylate 
• 172875-74-0 1-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester 
• 144690-86-8 ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-hydroxymethyl-2-propylimidazole-5-carboxylate 
• 154237-79-3 1-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-hydroxymethyl-2-propyl-1H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

ANGIOTENSIN II ANTAGONIST 1-BIPHENYLMETHYLIMIDAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the following formula (I) or the formula (I) p : STR1 wherein R 1 is alkyl or alkenyl; R 2 and R 3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R 4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula--SiR a R b R c, in which R a, R b and R c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R 5 is carboxy or--CONR 8 R 9, wherein R 8 and R 9 hydrogens or alkyl, or R 8 and R 9 together form alkylene; R 6 is hydrogen, alkyl, alkoxy or halogen; R. sup.7 is carboxy or tetrazol-5-yl; R p. sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R p 2 is a single bond, alkylene or alkylidene; R p 3 and R p 4 are each hydrogen or alkyl; R. sub.p 6 is carboxy or tetrazol-5-yl; and X p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.