144690-97-1

Basic information

• Product Name: 1H-Imidazole-5-carboxylic acid, 1-[[2'-[[(1,1-dimethylethyl)amino]carbonyl][1,1'-biphenyl]-4-yl]methyl]-4-(1 -hydroxy-1-methylethyl)-2-propyl-, ethyl ester
• CAS NO: 144690-97-1
• Molecular Formula: C30H39N3O4
• Molecular Weight: 505.657
• Mol File: 144690-97-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-5-carboxylic acid, 1-[[2'-[[(1,1-dimethylethyl)amino]carbonyl][1,1'-biphenyl]-4-yl]methyl]-4-(1 -hydroxy-1-methylethyl)-2-propyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-5-carboxylic acid, 1-[[2'-[[(1,1-dimethylethyl)amino]carbonyl][1,1'-biphenyl]-4-yl]methyl]-4-(1 -hydroxy-1-methylethyl)-2-propyl-, ethyl ester(144690-97-1)
• EPA Substance Registry System: 1H-Imidazole-5-carboxylic acid, 1-[[2'-[[(1,1-dimethylethyl)amino]carbonyl][1,1'-biphenyl]-4-yl]methyl]-4-(1 -hydroxy-1-methylethyl)-2-propyl-, ethyl ester(144690-97-1)

Safety Data

• Hazardous Substances Data: 144690-97-1(Hazardous Substances Data)

Usage

Molecular structure

The compound has a complex molecular structure with a heterocyclic imidazole ring and a carboxylic acid functional group, as well as a biphenyl moiety and a tertiary amine functional group substituted with a t-butyl carbamoyl group. It also has a hydroxyethyl and isopropyl group attached to the carbon backbone.

Functional groups

The compound contains several functional groups, including an imidazole ring, a carboxylic acid group, a biphenyl group, a tertiary amine group, a t-butyl carbamoyl group, a hydroxyethyl group, and an isopropyl group.

Ester compound

The compound is an ester of 1H-imidazole-5-carboxylic acid, which means it has an ethoxycarbonyl group attached to the imidazole ring.

Potential applications

Given its complex structure and diverse functional groups, the compound may have various applications in pharmaceuticals, materials science, or organic synthesis.

Physical and chemical properties

The physical and chemical properties of the compound are not specified in the given material, but they may vary depending on the specific functional groups and molecular structure.

Molecular weight

The molecular weight of the compound is not specified in the given material, but it can be calculated based on its molecular formula.

Downstream Products

• 144690-96-0 1-[{2'-cyanobiphenyl-4-yl}methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazol-5-carboxylic acid ethyl ester 

Relevant articles and documents

ANGIOTENSIN II ANTAGONIST 1-BIPHENYLMETHYLIMIDAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the following formula (I) or the formula (I) p : STR1 wherein R 1 is alkyl or alkenyl; R 2 and R 3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R 4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula--SiR a R b R c, in which R a, R b and R c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R 5 is carboxy or--CONR 8 R 9, wherein R 8 and R 9 hydrogens or alkyl, or R 8 and R 9 together form alkylene; R 6 is hydrogen, alkyl, alkoxy or halogen; R. sup.7 is carboxy or tetrazol-5-yl; R p. sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R p 2 is a single bond, alkylene or alkylidene; R p 3 and R p 4 are each hydrogen or alkyl; R. sub.p 6 is carboxy or tetrazol-5-yl; and X p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.