14472-80-1

Basic information

• Product Name: Cyclohexanone, 4-(4-chlorophenyl)-
• Synonyms: Cyclohexanone, 4-(4-chlorophenyl)-;4-(4-chlorophenyl)cyclohexanone;4-(p-Chlorophenyl)cyclohexanone
• CAS NO: 14472-80-1
• Molecular Formula: C₁₂H₁₃ClO
• Molecular Weight: 208.68
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 14472-80-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 138-141 °C
• Boiling Point: 323.664 °C at 760 mmHg
• Flash Point: 171.767 °C
• Appearance: colorless liquid
• Density: 1.165g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: Cyclohexanone, 4-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(4-chlorophenyl)-(14472-80-1)
• EPA Substance Registry System: Cyclohexanone, 4-(4-chlorophenyl)-(14472-80-1)

Safety Data

• Hazardous Substances Data: 14472-80-1(Hazardous Substances Data)

Usage

Description

Cyclohexanone, 4-(4-chlorophenyl)-, also known as 4-(4-Chlorophenyl)cyclohexanone, is an organic compound with the CAS number 14472-80-1. It is a white solid and is primarily used in organic synthesis due to its unique chemical structure and properties.

Uses

Used in Organic Synthesis:
Cyclohexanone, 4-(4-chlorophenyl)is used as a key intermediate in the synthesis of various organic compounds. Its chemical structure allows for a wide range of reactions, making it a versatile building block in the development of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Cyclohexanone, 4-(4-chlorophenyl)is used as a starting material for the synthesis of various pharmaceutical compounds. Its unique structure can be modified to create new drugs with specific therapeutic properties, contributing to the development of novel treatments for various diseases.
Used in Chemical Industry:
Cyclohexanone, 4-(4-chlorophenyl)is also used in the chemical industry for the production of various chemicals and materials. Its versatility in organic synthesis makes it a valuable component in the creation of new chemical products, such as plastics, coatings, and adhesives.
Used in Research and Development:
In the field of research and development, Cyclohexanone, 4-(4-chlorophenyl)is utilized as a model compound for studying various chemical reactions and mechanisms. Its unique properties make it an ideal candidate for understanding the behavior of similar compounds and developing new synthetic strategies.

InChI:InChI=1/C12H13ClO/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-2,5-6,10H,3-4,7-8H2

Upstream product

• 930766-09-9 4-(4-chlorophenyl)cyclohexan-1-ol 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 155098-65-0 4-(4-oxocyclohexyl)phenyl trifluoromethanesulfonate 
• 1409956-58-6 2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 106-39-8 bromochlorobenzene 
• 36716-75-3 4-(p-chlorophenyl)-3-cyclohexen-1-one 
• 637-87-6 1-Chloro-4-iodobenzene 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 126991-59-1 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 126991-60-4 4-(4-chlorophenyl)cyclohex-3-enone monoehtylene ketal 
• 25253-51-4 4-(4-chlorophenyl)cyclohexanone monoehtylene ketal 
• 36716-71-9 4-(4-chlorophenyl)-4-hydroxycyclohexanone 
• 101598-25-8 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester 

Downstream Products

• 98322-65-7 4-(4-Chloro-phenyl)-cyclohexanol 
• 1297474-44-2 C₁₅H₁₁ClN₂OS 
• 1297474-55-5 C₁₉H₁₁ClN₂O₂S 
• 1297474-20-4 C₁₉H₁₃ClN₂O₃S 
• 1297474-35-1 C₁₅H₁₅ClN₂OS 
• 1402080-52-7 5-(4-chlorophenyl)oxepan-2-one 
• 930766-09-9 (1S,4S)-4-(4-chlorophenyl)cyclohexan-1-ol 
• 1421369-93-8 4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate 
• 1409956-67-7 cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-62-2 2-(4-(4-chlorophenyl)cyclohex-1-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one 

Relevant articles and documents

Desymmetrizing Isomerization of Alkene via Thiazolinyl Iminoquinoline Cobalt Catalysis

We report a cobalt-catalyzed desymmetrizing isomerization of exo-cyclic alkenes to generate chiral 1-methylcyclohexene derivatives with good yields and enantioselectivities. A novel chiral thiazolinyl iminoquinoline ligand and its cobalt complex were desi

Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation

An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.

Method for synthesizing 4-(4-chlorphenyl)cyclohexanone

The invention relates to the field of organic synthesis and discloses a method for synthesizing a chemical intermediate 4-(4-chlorphenyl)cyclohexanone. The method includes the steps that firstly, 4-isopropenyl chlorobenzene is mixed with an organic solvent, N-bromo-succinimide is added for reaction for 1-6 h, solid is obtained, washed and dried after the reaction is completed, a compound 2 is obtained, a quenching reaction is carried out, extraction is conducted, an organic phase is obtained, and the compound 2 is obtained; secondly, the compound 2 and diethyl 1,3-acetonedicarboxylate are dissolved in alcohol, sodium alcoholate is added for reaction for 8-20 h, concentration is conducted after the reaction is completed, and a compound 3 is obtained; thirdly, the compound 3 is mixed with alcohol, an alkaline solution is added for a reflux reaction for 3-15 h, the product is adjusted to be alkalescent after the reaction is completed, and an organic phase is obtained, washed and dried after extraction. According to the synthesis method, raw materials are easy to obtain, reaction conditions are mild, selectivity is high, aftertreatment has good operability, the yield is high, production is easy to enlarge, and the method is more environmentally friendly.