1447446-98-1

Basic information

• Product Name: C₉₈H₁₅₄N₄O₁₃
• Synonyms: C₉₈H₁₅₄N₄O₁₃
• CAS NO: 1447446-98-1
• Molecular Weight: 1596.32
• Mol File: 1447446-98-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₉₈H₁₅₄N₄O₁₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₉₈H₁₅₄N₄O₁₃(1447446-98-1)
• EPA Substance Registry System: C₉₈H₁₅₄N₄O₁₃(1447446-98-1)

Safety Data

• Hazardous Substances Data: 1447446-98-1(Hazardous Substances Data)

Upstream product

• 1447446-97-0 N-(2-aminoethyl)-3,4,5-tris(octadecyloxy)benzamide hydrochloride 
• 74405-40-6 5’-O-(4,4’-dimethoxytriphenylmethyl)thymidine-3’-O-succinate 

Downstream Products

• 1447446-99-2 C₇₇H₁₃₆N₄O₁₁ 

Relevant articles and documents

Liquid-phase RNA synthesis by using alkyl-chain-soluble support

Recent progress in the RNA therapeutics has increased demand for the synthesis of large quantities of oligoribonucleotides. The assembly of RNA oligomers relies mainly on solid-phase approaches. These allow rapid product purification and the ability to drive a target reaction to completion through the use of excess reagents. Despite the known advantages of solid-phase synthesis, some issues in the process remain to be addressed, such as low and limited scale, reagent accessibility, and the use of a very large excess of reagents. Herein, we report a highly efficient and practical method of liquid-phase synthesis of RNA oligomers by using alkyl-chain-soluble support. We demonstrate the utility of the liquid-phase method through 21-mer RNA synthesis on a gram scale. The assembly of RNA oligomers relies principally on solid-phase approaches, although some alternative methods have been developed to date. A highly efficient and practical method of liquid-phase synthesis for RNA oligomers by using an alkyl-chain-type soluble support is reported. The utility of the liquid-phase method through 21-mer RNA synthesis on a gram scale is described (see scheme). Copyright