1447735-57-0

Basic information

• Product Name: 6-(3-(trifluoromethyl)benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine
• CAS NO: 1447735-57-0
• Molecular Weight: 344.296
• Mol File: 1447735-57-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(3-(trifluoromethyl)benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-(trifluoromethyl)benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine(1447735-57-0)
• EPA Substance Registry System: 6-(3-(trifluoromethyl)benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine(1447735-57-0)

Safety Data

• Hazardous Substances Data: 1447735-57-0(Hazardous Substances Data)

Upstream product

• 52494-53-8 6-chloro-1,2,4-triazolo<3,4-a>phthalazine 
• 349-75-7 3-(trifluoromethyl)benzyl alcohol 
• 51935-42-3 1-chloro-4-hydrazinophthalazine 
• 4752-10-7 1,4-dichlorophthalazine 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4] triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives

With the aim of finding new anticonvulsant drugs, new 6-substituted-[1,2,4] triazolo[3,4-a] (tetrazolo[5,1-a]) phthalazine derivatives (1-34) have been designed and synthesized. All the compounds were evaluated for their anticonvulsant activities using the maximal electroshock test (MES). Most of the synthesized compounds exhibited potent anticonvulsant activities in the MES. The most promising compound 14 showed significant anticonvulsant activity in MES test with ED50 value of 9.3 mg/kg. It displayed a wide margin of safety with protective index much higher than the standard drug Carbamazepine. And the potency of compound 14 against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide and 3-Mercaptopropionic acid in the chemical-induced seizure tests suggested that compound 14 displayed wide spectrum of activity in several models.