1447964-08-0

Basic information

• Product Name: (Z)-2-(3-fluorophenyl)-4-(2-(piperidin-1-yl)benzylidene)-oxazol-5(4H)-one
• Synonyms: (Z)-2-(3-fluorophenyl)-4-(2-(piperidin-1-yl)benzylidene)-oxazol-5(4H)-one
• CAS NO: 1447964-08-0
• Molecular Weight: 350.392
• Mol File: 1447964-08-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-(3-fluorophenyl)-4-(2-(piperidin-1-yl)benzylidene)-oxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(3-fluorophenyl)-4-(2-(piperidin-1-yl)benzylidene)-oxazol-5(4H)-one(1447964-08-0)
• EPA Substance Registry System: (Z)-2-(3-fluorophenyl)-4-(2-(piperidin-1-yl)benzylidene)-oxazol-5(4H)-one(1447964-08-0)

Safety Data

• Hazardous Substances Data: 1447964-08-0(Hazardous Substances Data)

Upstream product

• 1711-07-5 3-fluorobenzoyl chloride 
• 366-47-2 N-(3-fluoro-benzoyl)-glycine 
• 34595-26-1 2-(piperidin-1-yl)benzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 
• 110-89-4 piperidine 

Relevant articles and documents

Lewis acid catalyzed formation of 3-amino-3-carboxy-tetrahydroquinoline derivatives via tandem 1,5-hydride transfer/cyclization process

A Sc(OTf)3-catalyzed intramolecular tandem 1,5-hydride transfer/cyclization process to construct 3-amino-3-carboxy-tetrahydroquinoline derivatives has been developed. The methodology gives access to a range of relatively complex tetrahydroquinolines (tetracyclic and pentacyclic heterocycles bearing spirocyclic skeleton and two stereogenic centers) in good to excellent yields with diastereoselectivities ranging from 57:43 to 73:27. The synthetic utility of the method was also demonstrated by an efficient ring opening derivatization reaction.