1448164-99-5

Basic information

• Product Name: 2-(octylsulfonyl)-1-phenylethan-1-one
• Synonyms: 2-(octylsulfonyl)-1-phenylethan-1-one
• CAS NO: 1448164-99-5
• Molecular Weight: 296.431
• Mol File: 1448164-99-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(octylsulfonyl)-1-phenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(octylsulfonyl)-1-phenylethan-1-one(1448164-99-5)
• EPA Substance Registry System: 2-(octylsulfonyl)-1-phenylethan-1-one(1448164-99-5)

Safety Data

• Hazardous Substances Data: 1448164-99-5(Hazardous Substances Data)

Upstream product

• 7795-95-1 octane-1-sulfonyl chloride 
• 2206-94-2 1-acetoxy-1-phenylethene 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 629-27-6 1-Iodooctane 
• 58115-02-9 sodium octanesulfinate 
• 536-74-3 phenylacetylene 
• 3944-71-6 1-octanesulfinic acid 
• 100-42-5 styrene 
• 1065131-41-0 n-octanesulfonyl hydrazide 

Downstream Products

• 614-47-1 1,3-diphenyl-propen-3-one 

Relevant articles and documents

Synthesis of β-Keto Sulfones via Coupling of Aryl/Alkyl Halides, Sulfur Dioxide and Silyl Enolates through Metal-Free Photoinduced C–X Bond Dissociation

A photoinduced sulfonylative coupling of aryl/alkyl halides, DABCO?(SO2)2 (1,4-diazabicyclo[2.2.2]octane-sulfur dioxide), and silyl enolates under metal-free conditions has been developed, giving rise to β-keto sulfones in good yields. This transformation proceeds smoothly at room temperature under ultraviolet irradiation with good tolerance of various functional groups. Aryl iodides/bromides and alkyl halides are all good substrates in the sulfonylative reaction. A plausible mechanism is proposed, which proceeds through a radical process under photoinduced conditions. (Figure presented.).

Aerobic oxidation in nanomicelles of aryl alkynes, in water at room temperature

On the basis of the far higher solubility of oxygen gas inside the hydrocarbon core of nanomicelles, metal and peroxide free aerobic oxidation of aryl alkynes to β-ketosulfones has been achieved in water at room temperature. Many examples are offered that illustrate broad functional group tolerance. The overall process is environmentally friendly, documented by the associated low E Factors. It's all happenin' in the micelle! The highly preferential dissolution of oxygen gas within the lipophilic cores inside nanomicelles leads to efficient trapping of in situ generated vinyl radicals. These intermediate radicals, derived from arylalkynes and sulfinic acids, lead to β-ketosulfone products, formed under especially mild and green conditions: no metals, no heating or cooling, recyclable aqueous media, and low E Factors.

Dioxygen-triggered oxidative radical reaction: Direct aerobic difunctionalization of terminal alkynes toward β-keto sulfones

An unprecedented dioxygen-triggered oxidative radical process was explored using dioxygen as the solely terminal oxidant, realizing aerobic oxidaitve difunctionalization of terminal alkynes toward β-keto sulfones with high selectivity. Operando IR experiments revealed that pyridine not only acts as a base to successfully surpress ATRA (atom transfer radical addition) process, but also plays a vital role in reducing the activity of sulfinic acids.