1448351-76-5Relevant articles and documents
Pd-PEPPSI-IPent-SiO2: A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow
Price, Gregory A.,Hassan, Abbas,Chandrasoma, Nalin,Bogdan, Andrew R.,Djuric, Stevan W.,Organ, Michael G.
, p. 13347 - 13350 (2017)
A silica-supported precatalyst, Pd-PEPPSI-IPent-SiO2, has been prepared and evaluated for its proficiency in the Negishi cross-coupling of hindered and electronically deactivated coupling partners. The precatalyst Pd-PEPPSI-IPent loaded onto packed bed columns shows high catalytic activity for the room-temperature coupling of deactivated/hindered biaryl partners. Also for the first time, the flowed Csp3–Csp2 coupling of secondary alkylzinc reagents to (hetero)aromatics has been achieved with high selectivity with Pd-PEPPSI-IPent-SiO2. These couplings required residence times as short as 3 minutes to effect completion of these challenging transformations with excellent selectivity for the nonrearranged product.