1448366-73-1

Basic information

• Product Name: 2,2-dibromo-1-(5-bromo-2,3,4-trimethoxyphenyl)ethanone
• Synonyms: 2,2-dibromo-1-(5-bromo-2,3,4-trimethoxyphenyl)ethanone
• CAS NO: 1448366-73-1
• Molecular Weight: 446.918
• Mol File: 1448366-73-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-dibromo-1-(5-bromo-2,3,4-trimethoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dibromo-1-(5-bromo-2,3,4-trimethoxyphenyl)ethanone(1448366-73-1)
• EPA Substance Registry System: 2,2-dibromo-1-(5-bromo-2,3,4-trimethoxyphenyl)ethanone(1448366-73-1)

Safety Data

• Hazardous Substances Data: 1448366-73-1(Hazardous Substances Data)

Upstream product

• 13909-73-4 2',3',4'-trimethoxyacetophenone 

Relevant articles and documents

Bronsted acidic ionic liquid accelerated halogenation of organic compounds with N-halosuccinimides (NXS)

The Bronsted-Acidic ionic liquid 1-methyl-3-(4-sulfobutyl) imidazolium triflate [BMIM(SO3H)][OTf] was demonstrated to act efficiently as solvent and catalyst for the halogenation of activated organic compounds with N-halosuccinimides (NXS) under mild conditions with short reaction times. Methyl aryl ketones were converted into a-halo and a,a-dihaloketones, depending on the quantity of NXS used. Ketones with activated aromatic rings were selectively halogenated, however in some cases mixtures of a-halogenated ketone and ring-halogenated ketones were obtained. Activated aromatics were regioselectively ring halogenated to give mono- and dihalo-substituted products. The [BMIM(SO3H)][OTf] ionic liquid (IL-A) was successfully reused eight times in a representative monohalogenation reaction with no noticeable decrease in efficiency. An effective halogenation scale-up in this IL is also presented. The reactivity trend and the observed chemo- and regioselectiivities point to an ET process in these IL-promoted halofunctionalization reactions.