14484-06-1

Basic information

• Product Name: N-(2-hydroxyethyl)-1H-benzimidazole-2-carboxamide
• Synonyms: N-(2-hydroxyethyl)-1H-benzimidazole-2-carboxamide
• CAS NO: 14484-06-1
• Molecular Weight: 205.216
• Mol File: 14484-06-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-hydroxyethyl)-1H-benzimidazole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyethyl)-1H-benzimidazole-2-carboxamide(14484-06-1)
• EPA Substance Registry System: N-(2-hydroxyethyl)-1H-benzimidazole-2-carboxamide(14484-06-1)

Safety Data

• Hazardous Substances Data: 14484-06-1(Hazardous Substances Data)

Upstream product

• 2849-93-6 2-benzimidazolecarboxylic acid 
• 141-43-5 ethanolamine 
• 1871-89-2 N,N'-bis-(2-hydroxyethyl)oxamide 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

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Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs)

A scaffold hopping strategy converted the known 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidine core (1 and 2) by cyclization to a fused [6 + 5+6] membered heterocyclic mGluR2 PAM scaffold. Pharmacophore guided structure?activity relationship (SAR) studies resulted in a series of potent and metabolically stable mGluR2 PAMs. A representative optimized compound (95) having the most balanced profile, demonstrated efficacy in the PCP-induced hyper-locomotion model in mice that revealed the new chemotype being a promising PAM lead targeting mGluR2 receptors and providing support for further translational studies.