1448604-92-9

Basic information

• Product Name: 3-hydroxy-3-methyl-5-phenylpent-4-ynoic acid
• Synonyms: 3-hydroxy-3-methyl-5-phenylpent-4-ynoic acid
• CAS NO: 1448604-92-9
• Molecular Weight: 204.225
• Mol File: 1448604-92-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-methyl-5-phenylpent-4-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-methyl-5-phenylpent-4-ynoic acid(1448604-92-9)
• EPA Substance Registry System: 3-hydroxy-3-methyl-5-phenylpent-4-ynoic acid(1448604-92-9)

Safety Data

• Hazardous Substances Data: 1448604-92-9(Hazardous Substances Data)

Upstream product

• 24697-35-6 Bis(trimethylsilyl) ketene acetal 
• 1817-57-8 4-phenyl-3-butyne-2-one 

Downstream Products

• 1448605-22-8 5-Bromo-4-hydroxy-4-methyl-6-phenyl-3,4-dihydro-2H-pyran-2-one 
• 1448605-24-0 5-Bromo-4-methyl-6-phenyl-2H-pyran-2-one 

Relevant articles and documents

First direct synthesis of 3-hydroxy-pent-4-ynoic acids. Application to the synthesis of pyran-2-ones

We describe a direct method for the synthesis of 3-hydroxy-pent-4-ynoic acids by the nucleophilic addition of bis-(TMS) ketene acetals to alkynones promoted by BF3·Et2O. A systematic study involving electron withdrawing and electron donor groups (R1=NO2, CF3, Br, Cl, H, Me, OMe) in the propargyl ketone reveals a strong dependence of electronic effects on the regiochemistry of the nucleophilic addition. Using a halolactonization protocol, we demonstrated the synthetic potential of these acids by their efficient transformation into new 5-bromo-3,4-dihydro-2H-pyran-2-ones.