1448780-05-9

Basic information

• Product Name: 2-(4'-amino-3-nitrophenyl)-6-hydroxybenzothiazole
• Synonyms: 2-(4'-amino-3-nitrophenyl)-6-hydroxybenzothiazole
• CAS NO: 1448780-05-9
• Molecular Weight: 287.299
• Mol File: 1448780-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4'-amino-3-nitrophenyl)-6-hydroxybenzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4'-amino-3-nitrophenyl)-6-hydroxybenzothiazole(1448780-05-9)
• EPA Substance Registry System: 2-(4'-amino-3-nitrophenyl)-6-hydroxybenzothiazole(1448780-05-9)

Safety Data

• Hazardous Substances Data: 1448780-05-9(Hazardous Substances Data)

Upstream product

• 833486-94-5 4-amino-3-nitrophenylboronic acid pinacol ester 
• 808755-67-1 6-hydroxy-2-bromo-benzothiazole 

Relevant articles and documents

Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki-Miyaura cross-coupling reactions

In positron emission tomography [11C]PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer's disease. Synthetic routes for the preparation of the precursor of [11C]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple one-step synthesis of the precursor of [11C]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [ 18F] precursor derivatives of PIB containing a nitro function.