144881-52-7

Basic information

• Product Name: 1-(4-BENZYLOXY-PHENYL)-PIPERAZINE
• Synonyms: 1-(4-BENZYLOXY-PHENYL)-PIPERAZINE;1-[4-(benzyloxy)phenyl]piperazine(SALTDATA: FREE);1-[4-(phenylmethoxy)phenyl]piperazine
• CAS NO: 144881-52-7
• Molecular Formula: C₁₇H₂₀N₂O
• Molecular Weight: 268.35
• Product Categories: pharmacetical
• Mol File: 144881-52-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-BENZYLOXY-PHENYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BENZYLOXY-PHENYL)-PIPERAZINE(144881-52-7)
• EPA Substance Registry System: 1-(4-BENZYLOXY-PHENYL)-PIPERAZINE(144881-52-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 144881-52-7(Hazardous Substances Data)

Usage

General Description

1-(4-Benzyloxy-phenyl)-piperazine is a chemical compound with a piperazine core structure and a benzyl-ether functional group attached to a phenyl ring. It is commonly used in the pharmaceutical industry as a starting material for the synthesis of various drug candidates, particularly antipsychotic and antidepressant medications. 1-(4-BENZYLOXY-PHENYL)-PIPERAZINE has also shown potential as a serotonin receptor agonist and has been studied for its potential therapeutic effects on conditions such as depression, anxiety, and schizophrenia. Additionally, 1-(4-Benzyloxy-phenyl)-piperazine has been identified as a potential precursor for the synthesis of novel psychoactive substances, raising concerns about its misuse and abuse. Its chemical properties and pharmacological effects make it an important compound for both research and medicinal applications.

Upstream product

• 7700-27-8 4-chlorophenyl benzyl ether 
• 106-48-9 4-chloro-phenol 
• 946-80-5 (benzyloxy)benzene 
• 140681-55-6 Selectfluor 
• 100-39-0 benzyl bromide 
• 158985-25-2 tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate 
• 943035-30-1 4-(4-benzyloxyphenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 110-85-0 piperazine 
• 6793-92-6 p-benzyloxyphenylbromide 

Downstream Products

• 144881-45-8 5-[4-(4-Benzyloxy-phenyl)-piperazin-1-ylmethyl]-4,5-dihydro-oxazol-2-ylamine 
• 398458-41-8 2-[4-(4-benzyloxy-phenyl)piperazin-1-yl]-4,5-dihydroimidazo[4,5,1-ij]quinolin-6-one ethylene ketal 
• 1526935-46-5 (R)-1-(4-(2-(¹⁸F)fluoroethoxy)phenyl)-4-(4-(7-hydroxychroman-2-yl)-3-azabutyl)piperazine 
• 1526935-40-9 1-(4-benzyloxyphenyl)-4-(2-aminoethyl)piperazine 
• 1526935-41-0 (R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine 
• 1526935-38-5 (R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine 
• 1526935-39-6 1-(4-benzyloxyphenyl)-4-(2-N-(tert-butylcarbamate)ethyl)piperazine 
• 56621-48-8 1-(4-hydroxyphenyl)piperazine 
• 1215855-23-4 acetic acid 3-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-phenyl ester 
• 1215855-24-5 N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide 
• 1247040-87-4 C₂₁H₂₆N₂O₃ 
• 1215855-50-7 acetic acid 4-{4-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-4-oxobutyryl}-phenyl ester 
• 1215855-75-6 2-{4-[4-(benzyloxy)phenyl]piperazin-1-yl}-2-oxoethyl acetate 

Relevant articles and documents

MALIC ENZYME INHIBITORS

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D2/3 receptors in their high-affinity state

Imaging of dopamine D2/3 receptors (D2/3R) can shed light on the nature of several neuropsychiatric disorders in which dysregulation of D2/3R signaling is involved. Agonist D2/3 tracers for PET/SPECT imaging are considered to be superior to antagonists because they are more sensitive to dopamine concentrations and may selectively label the high-affinity receptor state. Carbon-11-labeled D2/3R agonists have been developed, but these short-lived tracers can be used only in centers with a cyclotron. Here, we report the development of a series of novel D2R agonist compounds based on the 2-aminomethylchromane (AMC) scaffold that provides ample opportunities for the introduction of longer-lived [ 18F] or [123I]. Binding experiments showed that several AMC compounds have a high affinity and selectivity for D2/3R and act as agonists. Two fluorine-containing compounds were [18F]-labeled, and both displayed specific binding to striatal D2/3R in rat brain slices in vitro. These findings encourage further in vivo evaluations.

PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE

The invention relates to compounds of formula (I), their synthesis and their use, in particular for detecting amyloid deposits in a patient.