1449123-25-4

Basic information

• Product Name: 1-(4-methoxyphenyl)-3-(thiophen-2-yl)propan-1-one
• Synonyms: 1-(4-methoxyphenyl)-3-(thiophen-2-yl)propan-1-one
• CAS NO: 1449123-25-4
• Molecular Weight: 246.33
• Mol File: 1449123-25-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxyphenyl)-3-(thiophen-2-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-3-(thiophen-2-yl)propan-1-one(1449123-25-4)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-3-(thiophen-2-yl)propan-1-one(1449123-25-4)

Safety Data

• Hazardous Substances Data: 1449123-25-4(Hazardous Substances Data)

Upstream product

• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 636-72-6 2-thiophenemethanol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Catalyst-free dehydrative α-alkylation of ketones with alcohols: Green and selective autocatalyzed synthesis of alcohols and ketones

Direct dehydrative α-alkylation reactions of ketones with alcohols are now realized under simple, practical, and green conditions without using external catalysts. These catalyst-free autocatalyzed alkylation methods can efficiently afford useful alkylated ketone or alcohol products in a one-pot manner and on a large scale by Ci￡C bond formation of the in situ generated intermediates with subsequent controllable and selective Meerwein-Pondorf-Verley-Oppenauer-type redox processes. Plain and simple: The title reaction has been realized under simple and practical conditions without using external catalysts, and can afford alkylated ketone or alcohol products in a one-pot manner and on a large scale. The reaction proceeds by Ci￡C bond formation of the in situ generated intermediates with subsequent controllable and selective Meerwein-Pondorf-Verley-Oppenauer-type redox processes. Copyright

Alkylation of Ketones Catalyzed by Bifunctional Iron Complexes: From Mechanistic Understanding to Application

Cyclopentadienone iron dicarbonyl complexes were applied in the alkylation of ketones with various aliphatic and aromatic ketones and alcohols via the borrowing hydrogen strategy in mild reaction conditions. DFT calculations and experimental works highlight the role of the transition metal Lewis pairs and the base. These iron complexes demonstrated a broad applicability in mild conditions and extended the scope of substrates.