1449276-37-2

Basic information

• Product Name: N-(2-fluoro-3-(trifluoromethyl)phenyl)-5,6,7-trimethoxyquinazolin-4-amine hydrochloride
• Synonyms: N-(2-fluoro-3-(trifluoromethyl)phenyl)-5,6,7-trimethoxyquinazolin-4-amine hydrochloride
• CAS NO: 1449276-37-2
• Molecular Weight: 433.79
• Mol File: 1449276-37-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-fluoro-3-(trifluoromethyl)phenyl)-5,6,7-trimethoxyquinazolin-4-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluoro-3-(trifluoromethyl)phenyl)-5,6,7-trimethoxyquinazolin-4-amine hydrochloride(1449276-37-2)
• EPA Substance Registry System: N-(2-fluoro-3-(trifluoromethyl)phenyl)-5,6,7-trimethoxyquinazolin-4-amine hydrochloride(1449276-37-2)

Safety Data

• Hazardous Substances Data: 1449276-37-2(Hazardous Substances Data)

Upstream product

• 123973-25-1 2-fluoro-3-(trifluoromethyl)aniline 
• 55496-54-3 4-chloro-5,6,7-trimethoxyquinazoline 

Relevant articles and documents

Synthesis and anticancer activities of 5,6,7-trimethoxy-N-phenyl(ethyl)-4- aminoquinazoline derivatives

A series of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline compounds was prepared by microwave irradiation and conventional heating methods. Compounds 6p, 6q , and 6x strongly inhibited extracellular regulated kinas-1/2 (ERK1/2) phosphorylation induced by epidermal growth factor (EGF) at 1.28 μM in PC3 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that all compounds had certain anticancer activities, and the IC50 values of 6x were 6.2 ± 0.9, 3.2 ± 0.1, and 3.1 ± 0.1 μM against PC3, BGC823, and Bcap37 cells, respectively. Acridine orange/ethidium bromide staining, Hoechst 33258 staining, DNA ladder, and flow cytometry analyses revealed that 6x induced cell apoptosis in PC3 cells, with apoptosis ratios of 11.6% at 1 μM and 31.8% at 10 μM after 72 h.