1449289-03-5

Basic information

• Product Name: 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide
• Synonyms: 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide
• CAS NO: 1449289-03-5
• Molecular Weight: 576.699
• Mol File: 1449289-03-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide(1449289-03-5)
• EPA Substance Registry System: 7-(4-(3-(1-(6-aminohexyl)-1H-1,2,3-triazol-4-yl)phenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide(1449289-03-5)

Safety Data

• Hazardous Substances Data: 1449289-03-5(Hazardous Substances Data)

Upstream product

• 1012054-59-9 CUDC-101 
• 349553-73-7 6-azido-hexylamine 

Downstream Products

• 1449289-00-2 2,2',2''-(10-(2-(6-(4-(3-(6-(7-(hydroxyamino)-7-oxoheptyloxy)-7-methoxyquinazolin-4-ylamino)phenyl)-1H-1,2,3-triazol-1-yl)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid 

Relevant articles and documents

Novel 64Cu-labeled CUDC-101 for in vivo PET imaging of histone deacetylases

We report the design, synthesis, and biological evaluation of a 64Cu-labeled histone deacetylase (HDAC) imaging probe, which was obtained by introduction of metal chelator through click reaction of HDAC inhibitor CUDC-101 and then radiolabeled with 64Cu. The resulting 64Cu-labeled compound 7 ([64Cu]7) was identified as a positron emission tomography (PET) imaging probe to noninvasively visualize HDAC expression in vivo. Cell based competitive assay established the specific binding of [64Cu]7 to HDACs. Biodistribution and small-animal microPET/CT studies further showed that [64Cu]7 had high tumor to background ratio in the MDA-MB-231 xenograft model, a triple-negative breast cancer with high expression of HDACs. To our knowledge, [64Cu]7 thus represents the first 64Cu-labeled PET HDAC imaging probe, which exhibits nanomolar range binding affinity and capability to imaging HDAC expression in triple-negative breast cancer in vivo.