1449424-02-5

Basic information

• Product Name: 12-(3-aminophenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-5(12H)-one
• CAS NO: 1449424-02-5
• Molecular Weight: 547.619
• Mol File: 1449424-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 12-(3-aminophenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-5(12H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 12-(3-aminophenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-5(12H)-one(1449424-02-5)
• EPA Substance Registry System: 12-(3-aminophenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-5(12H)-one(1449424-02-5)

Safety Data

• Hazardous Substances Data: 1449424-02-5(Hazardous Substances Data)

Upstream product

• 1449424-01-4 (3-(2-((3H-[1,2,3]triazolo[4,5-b]pyridine-3-yl)oxy)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)carbamic acid tert-butylester 
• 1449423-81-7 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-chloropyrimidine-5-carboxylic acid 
• 1429497-82-4 ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-chloropyrimidine-5-carboxylate 
• 68621-88-5 (3-aminophenyl)carbamic acid tert-butyl ester 
• 51940-64-8 ethyl 2,4-dichloropyrimidine-5-carboxylate 

Downstream Products

• 1449423-87-3 N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide 

Relevant articles and documents

Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants

Catching the mutants: Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives (see example) were identified as specific inhibitors of EGFRT790M mutants. The compounds bound with T790M or L858R/T790M mutants with significantly lower Kd values